ENSG00000162434


Homo sapiens

Features
Gene ID: ENSG00000162434
  
Biological name :JAK1
  
Synonyms : JAK1 / Janus kinase 1 / P23458
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p31.3
Gene start: 64833229
Gene end: 64966504
  
Corresponding Affymetrix probe sets: 1552610_a_at (Human Genome U133 Plus 2.0 Array)   1552611_a_at (Human Genome U133 Plus 2.0 Array)   201648_at (Human Genome U133 Plus 2.0 Array)   239695_at (Human Genome U133 Plus 2.0 Array)   240613_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343204
NCBI entrez gene - 3716     See in Manteia.
OMIM - 147795
RefSeq - NM_001321853
RefSeq - NM_001321854
RefSeq - NM_001321855
RefSeq - NM_001321856
RefSeq - NM_001321857
RefSeq - NM_002227
RefSeq - XM_017001212
RefSeq - NM_001320923
RefSeq - NM_001321852
RefSeq Peptide - NP_001307852
RefSeq Peptide - NP_001308782
RefSeq Peptide - NP_001308783
RefSeq Peptide - NP_001308784
RefSeq Peptide - NP_001308785
RefSeq Peptide - NP_001308786
RefSeq Peptide - NP_002218
RefSeq Peptide - NP_001308781
swissprot - P23458
Ensembl - ENSG00000162434
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak1ENSDARG00000020625Danio rerio
 JAK1ENSGALG00000011031Gallus gallus
 Jak1ENSMUSG00000028530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TYK2 / P29597 / tyrosine kinase 2ENSG0000010539745
JAK2 / O60674 / Janus kinase 2ENSG0000009696842
JAK3 / P52333 / Janus kinase 3ENSG0000010563938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020776  Tyrosine-protein kinase, non-receptor Jak1
 IPR035963  FERM superfamily, second domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038110 interleukin-2-mediated signaling pathway IDA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0038113 interleukin-9-mediated signaling pathway TAS
 biological_processGO:0038114 interleukin-21-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway TAS
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex
 ENSG00000100385 IL2RB / P14784 / interleukin 2 receptor subunit beta  / complex / reaction
 ENSG00000109471 IL2 / P60568 / interleukin 2  / complex / reaction
 ENSG00000110324 IL10RA / Q13651 / interleukin 10 receptor subunit alpha  / complex / reaction
 ENSG00000113302 IL12B / P29460 / interleukin 12B  / complex
 ENSG00000124334 IL9R / Q01113 / interleukin 9 receptor  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / complex
 ENSG00000128342 LIF / P15018 / LIF, interleukin 6 family cytokine  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000104432 IL7 / P13232 / interleukin 7  / complex / reaction
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex
 ENSG00000134460 IL2RA / P01589 / interleukin 2 receptor subunit alpha  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000095752 IL11 / P20809 / interleukin 11  / complex / reaction
 ENSG00000136244 IL6 / P05231 / interleukin 6  / complex / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000150281 CTF1 / Q16619 / cardiotrophin 1  / complex / reaction
 ENSG00000162892 IL24 / Q13007 / interleukin 24  / complex
 ENSG00000142677 Q8N6P7 / IL22RA1 / interleukin 22 receptor subunit alpha 1  / complex / reaction
 ENSG00000142224 IL19 / Q9UHD0 / interleukin 19  / complex
 ENSG00000145623 OSMR / Q99650 / oncostatin M receptor  / complex / reaction
 ENSG00000164136 IL15 / P40933 / interleukin 15  / complex
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000145839 IL9 / P15248 / interleukin 9  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex / reaction
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / complex / reaction
 ENSG00000169194 IL13 / P35225 / interleukin 13  / complex
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / complex
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / complex / reaction
 ENSG00000175505 CLCF1 / Q9UBD9 / cardiotrophin like cytokine factor 1  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / complex
 ENSG00000164509 IL31RA / Q8NI17 / interleukin 31 receptor A  / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000168685 IL7R / P16871 / interleukin 7 receptor  / complex / reaction
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000182393 IFNL1 / Q8IU54 / interferon lambda 1  / complex / reaction
 ENSG00000099985 OSM / P13725 / oncostatin M  / complex / reaction
 ENSG00000111537 IFNG / P01579 / interferon gamma  / complex / reaction
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex / reaction
 ENSG00000111536 IL26 / Q9NPH9 / interleukin 26  / complex
 ENSG00000138684 IL21 / Q9HBE4 / interleukin 21  / complex
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / complex / reaction
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000185436 IFNLR1 / Q8IU57 / interferon lambda receptor 1  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000096996 P42701 / IL12RB1 / interleukin 12 receptor subunit beta 1  / complex
 ENSG00000174564 IL20RB / Q6UXL0 / interleukin 20 receptor subunit beta  / complex
 ENSG00000127318 IL22 / Q9GZX6 / interleukin 22  / complex / reaction
 ENSG00000183709 IFNL2 / Q8IZJ0 / interferon lambda 2  / complex
 ENSG00000103522 IL21R / Q9HBE5 / interleukin 21 receptor  / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000242689 CNTF / P26441 / ciliary neurotrophic factor  / complex / reaction
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000122756 CNTFR / P26992 / ciliary neurotrophic factor receptor  / complex / reaction
 ENSG00000136634 IL10 / P22301 / interleukin 10  / complex / reaction
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / complex
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000006016 CRLF1 / O75462 / cytokine receptor like factor 1  / complex / reaction
 ENSG00000197110 IFNL3 / Q8IZI9 / interferon lambda 3  / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / complex
 ENSG00000137070 IL11RA / Q14626 / interleukin 11 receptor subunit alpha  / complex / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000016402 IL20RA / Q9UHF4 / interleukin 20 receptor subunit alpha  / complex
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / complex / reaction
 ENSG00000162891 IL20 / Q9NYY1 / interleukin 20  / complex
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000204671 IL31 / Q6EBC2 / interleukin 31  / complex
 ENSG00000134470 IL15RA / Q13261 / interleukin 15 receptor subunit alpha  / complex
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / complex / reaction






 

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