ENSG00000096968


Homo sapiens

Features
Gene ID: ENSG00000096968
  
Biological name :JAK2
  
Synonyms : JAK2 / Janus kinase 2 / O60674
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.1
Gene start: 4984390
Gene end: 5128183
  
Corresponding Affymetrix probe sets: 1562031_at (Human Genome U133 Plus 2.0 Array)   205841_at (Human Genome U133 Plus 2.0 Array)   205842_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489812
Ensembl peptide - ENSP00000490624
Ensembl peptide - ENSP00000371067
NCBI entrez gene - 3717     See in Manteia.
OMIM - 147796
RefSeq - NM_001322199
RefSeq - NM_001322194
RefSeq - NM_001322195
RefSeq - NM_001322196
RefSeq - NM_001322198
RefSeq - NM_001322204
RefSeq - NM_004972
RefSeq Peptide - NP_004963
RefSeq Peptide - NP_001309127
RefSeq Peptide - NP_001309128
RefSeq Peptide - NP_001309133
RefSeq Peptide - NP_001309123
RefSeq Peptide - NP_001309124
RefSeq Peptide - NP_001309125
swissprot - O60674
swissprot - A0A1B0GVR5
swissprot - A0A1B0GTR9
Ensembl - ENSG00000096968
  
Related genetic diseases (OMIM): 133100 - Erythrocytosis, somatic, 133100
  601626 - Leukemia, acute myeloid, somatic, 601626
  254450 - Myelofibrosis, somatic, 254450
  263300 - Polycythemia vera, somatic, 263300
  614521 - Thrombocythemia 3, 614521
  600880 - {Budd-Chiari syndrome, somatic}, 600880
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak2aENSDARG00000104808Danio rerio
 jak2bENSDARG00000018882Danio rerio
 JAK2ENSGALG00000015027Gallus gallus
 Jak2ENSMUSG00000024789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JAK3 / P52333 / Janus kinase 3ENSG0000010563949
JAK1 / P23458 / Janus kinase 1ENSG0000016243443
TYK2 / P29597 / tyrosine kinase 2ENSG0000010539739


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020693  Tyrosine-protein kinase, non-receptor Jak2
 IPR035588  Janus kinase 2, pseudokinase domain
 IPR035589  Janus kinase 2, catalytic domain
 IPR035860  Tyrosine-protein kinase JAK2, SH2 domain
 IPR035963  FERM superfamily, second domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007165 signal transduction ISS
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030041 actin filament polymerization NAS
 biological_processGO:0030154 cell differentiation ISS
 biological_processGO:0030218 erythrocyte differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035409 histone H3-Y41 phosphorylation IDA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0035722 interleukin-12-mediated signaling pathway IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038155 interleukin-23-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0042976 activation of Janus kinase activity ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043392 negative regulation of DNA binding ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050867 positive regulation of cell activation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:0060399 positive regulation of growth hormone receptor signaling pathway ISS
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061180 mammary gland epithelium development ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway TAS
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070671 response to interleukin-12 IDA
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
 biological_processGO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
 biological_processGO:1904037 positive regulation of epithelial cell apoptotic process IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005901 caveola ISS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005143 interleukin-12 receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0033130 acetylcholine receptor binding IEA
 molecular_functionGO:0035401 histone kinase activity (H3-Y41 specific) IDA
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000225 Gingival bleeding 
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 HP:0000360 Tinnitus "Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation." [Cochrane:ab005233]
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 HP:0000421 Epistaxis 
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 HP:0000822 Hypertension "High blood pressure." [HPO:curators]
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 HP:0000952 Jaundice "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." [HPO:curators]
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 HP:0000975 Hyperhidrosis "An abnormally increased perspiration." [HPO:probinson]
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 HP:0000978 Ecchymoses 
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 HP:0000989 Pruritus "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]
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 HP:0001050 Plethora 
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 HP:0001082 Cholecystitis 
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 HP:0001123 Visual field defects 
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 HP:0001250 Seizures "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson]
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 HP:0001260 Dysarthria "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." [HPO:curators]
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 HP:0001279 Syncope "Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. This term refers to an abnormally increased disposition to syncope." [HPO:curators]
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 HP:0001297 Stroke 
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 HP:0001342 Cerebral hemorrhage "A cerebral hemorrhage (or intracerebral hemorrhage, ICH), is a type of intracranial hemorrhage that occurs within the brain tissue itself." [HPO:curators]
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 HP:0001394 Cirrhosis 
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 HP:0001409 Portal hypertension 
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 HP:0001428 Somatic mutation 
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 HP:0001541 Ascites 
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 HP:0001658 Myocardial infarction 
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 HP:0001681 Angina pectoris 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001824 Weight loss 
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 HP:0001873 Thrombocytopenia 
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 HP:0001892 Bleeding diathesis "An abnormal susceptibility to bleeding because of a defect in coagulation." [HPO:curators]
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 HP:0001894 Thrombocytosis 
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 HP:0001898 Increased red blood cell mass 
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 HP:0001899 Increased hematocrit 
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 HP:0001900 Increased hemoglobin 
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 HP:0001907 Thromboembolism 
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 HP:0001945 Fever 
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 HP:0001974 Leukocytosis "An abnormal increase in the number of `leukocytes` (CL:0000738) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0001977 Thrombosis 
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 HP:0002024 Malabsorption 
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 HP:0002027 Abdominal pain 
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 HP:0002040 Esophageal varices 
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 HP:0002092 Pulmonary hypertension 
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 HP:0002093 Respiratory insufficiency 
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 HP:0002204 Pulmonary embolism 
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 HP:0002239 Gastrointestinal hemorrhage 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002315 Headache "Cephalgia, or pain in the head originating from the cerebral vault." [HPO:curators]
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 HP:0002321 Vertigo "An abnormal sensation of spinning while the body is actually stationary." [HPO:curators]
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 HP:0002326 Transient ischemic attack 
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 HP:0002488 Acute leukemia 
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 HP:0002586 Peritonitis 
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 HP:0002637 Cerebral ischemia 
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 HP:0002639 Budd-Chiari syndrome 
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 HP:0002641 Peripheral thrombosis 
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 HP:0002829 Arthralgia 
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 HP:0002863 Myelodysplasia 
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 HP:0002875 Exertional dyspnea 
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 HP:0002910 Elevated transaminases "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." [HPO:curators]
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 HP:0003010 Prolonged bleeding time 
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 HP:0003401 Paresthesia "Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause." [HPO:curators]
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 HP:0003745 Sporadic 
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 HP:0004417 Intermittent claudication 
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 HP:0004420 Arterial thrombosis 
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 HP:0004808 Acute myeloid leukemia "A form of leukemia characterized by overproduction of an early myeloid cell." [HPO:curators]
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 HP:0004936 Venous thrombosis 
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 HP:0004950 Peripheral arterial disease 
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 HP:0005214 Intestinal obstruction 
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 HP:0005244 Gastrointestinal infarctions 
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 HP:0005268 Increased risk of spontaneous abortion 
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 HP:0005506 Chronic myelogenous leukemia 
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 HP:0005513 Increased megakaryocyte precursor cells 
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 HP:0005547 Myeloproliferative disorder 
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 HP:0006554 Acute hepatic failure "Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver." [HPO:curators]
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 HP:0011875 Abnormal platelet morphology "An anomaly in platelet form, ultrastructure, or intracellular organelles." [DDD:kfreson]
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 HP:0011974 Myelofibrosis "Replacement of bone marrow by fibrous tissue." [HPO:probinson]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0030242 Portal vein thrombosis "Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the sup-erior and inferior mesenteric veins." [HPO:probinson, pmid:21960890]
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 HP:0100576 Amaurosis fugax "A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition." [HPO:sdoelken]
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 HP:0100749 Chest pain 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex / reaction
 ENSG00000113302 IL12B / P29460 / interleukin 12B  / complex / reaction
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / complex / reaction
 ENSG00000128342 LIF / P15018 / LIF, interleukin 6 family cytokine  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000095752 IL11 / P20809 / interleukin 11  / complex / reaction
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / complex / reaction
 ENSG00000136244 IL6 / P05231 / interleukin 6  / complex / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000150281 CTF1 / Q16619 / cardiotrophin 1  / complex / reaction
 ENSG00000141506 PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5  / complex / reaction
 ENSG00000174697 LEP / leptin / P41159  / complex / reaction
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex / reaction
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / complex / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000175505 CLCF1 / Q9UBD9 / cardiotrophin like cytokine factor 1  / complex / reaction
 ENSG00000159128 IFNGR2 / P38484 / interferon gamma receptor 2  / complex
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000165458 INPPL1 / O15357 / inositol polyphosphate phosphatase like 1  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000120833 SOCS2 / O14508 / suppressor of cytokine signaling 2  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000096996 P42701 / IL12RB1 / interleukin 12 receptor subunit beta 1  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex / reaction
 ENSG00000178188 SH2B1 / Q9NRF2 / SH2B adaptor protein 1  / complex / reaction
 ENSG00000111252 SH2B3 / Q9UQQ2 / SH2B adaptor protein 3  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex
 ENSG00000137070 IL11RA / Q14626 / interleukin 11 receptor subunit alpha  / complex / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000162594 IL23R / Q5VWK5 / interleukin 23 receptor  / complex / reaction
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / complex / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex / reaction
 ENSG00000114737 CISH / Q9NSE2 / cytokine inducible SH2 containing protein  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000105851 P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma  / complex / reaction
 ENSG00000242689 CNTF / P26441 / ciliary neurotrophic factor  / complex / reaction
 ENSG00000116678 LEPR / P48357 / leptin receptor  / complex
 ENSG00000168918 INPP5D / Q92835 / inositol polyphosphate-5-phosphatase D  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000122756 CNTFR / P26992 / ciliary neurotrophic factor receptor  / complex / reaction
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / complex / reaction
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex / reaction
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000027697 IFNGR1 / P15260 / interferon gamma receptor 1  / complex
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex / reaction
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / reaction
 ENSG00000099985 OSM / P13725 / oncostatin M  / complex / reaction
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex
 ENSG00000111537 IFNG / P01579 / interferon gamma  / complex / reaction
 ENSG00000110944 IL23A / Q9NPF7 / interleukin 23 subunit alpha  / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex / reaction
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000145623 OSMR / Q99650 / oncostatin M receptor  / complex / reaction
 ENSG00000169194 IL13 / P35225 / interleukin 13  / complex / reaction
 ENSG00000171150 SOCS5 / O75159 / suppressor of cytokine signaling 5  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000006016 CRLF1 / O75462 / cytokine receptor like factor 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex / reaction






 

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