ENSG00000160691


Homo sapiens

Features
Gene ID: ENSG00000160691
  
Biological name :SHC1
  
Synonyms : P29353 / SHC1 / SHC adaptor protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 154962298
Gene end: 154974395
  
Corresponding Affymetrix probe sets: 201469_s_at (Human Genome U133 Plus 2.0 Array)   214853_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404908
Ensembl peptide - ENSP00000398864
Ensembl peptide - ENSP00000401303
Ensembl peptide - ENSP00000357430
Ensembl peptide - ENSP00000357434
Ensembl peptide - ENSP00000357435
Ensembl peptide - ENSP00000357438
Ensembl peptide - ENSP00000396162
Ensembl peptide - ENSP00000396333
Ensembl peptide - ENSP00000398441
NCBI entrez gene - 6464     See in Manteia.
OMIM - 600560
RefSeq - XM_017002083
RefSeq - NM_001130040
RefSeq - NM_001130041
RefSeq - NM_001202859
RefSeq - NM_003029
RefSeq - NM_183001
RefSeq - XM_005245449
RefSeq - XM_005245451
RefSeq - XM_011509892
RefSeq - XM_011509893
RefSeq - XM_011509894
RefSeq - XM_011509897
RefSeq - XM_011509898
RefSeq - XM_017002081
RefSeq - XM_017002082
RefSeq Peptide - NP_892113
RefSeq Peptide - NP_001123512
RefSeq Peptide - NP_001123513
RefSeq Peptide - NP_001189788
RefSeq Peptide - NP_003020
swissprot - Q5T182
swissprot - Q5T188
swissprot - Q5T187
swissprot - X6R6D0
swissprot - H0Y539
swissprot - P29353
swissprot - Q5T181
Ensembl - ENSG00000160691
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 shc1ENSDARG00000075437Danio rerio
 SHC1ENSGALG00000039775Gallus gallus
 Shc1ENSMUSG00000042626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SHC4 / Q6S5L8 / SHC adaptor protein 4ENSG0000018563449
SHC2 / P98077 / SHC adaptor protein 2ENSG0000012994648
SHC3 / Q92529 / SHC adaptor protein 3ENSG0000014808248


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006019  Phosphotyrosine interaction domain, Shc-like
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR029586  SHC-transforming protein 1
 IPR035676  SH2 adaptor protein C, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity TAS
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway TAS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038110 interleukin-2-mediated signaling pathway TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045740 positive regulation of DNA replication ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0070435 Shc-EGFR complex ISS
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding ISS
 molecular_functionGO:0005158 insulin receptor binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0048408 epidermal growth factor binding IEA


Pathways (from Reactome)
Pathway description
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin alphaIIb beta3 signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / complex / reaction
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000158869 FCER1G / P30273 / Fc fragment of IgE receptor Ig  / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / complex / reaction
 ENSG00000017427 IGF1 / P05019 / insulin like growth factor 1  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000140443 IGF1R / P08069 / insulin like growth factor 1 receptor  / complex / reaction
 ENSG00000149534 MS4A2 / Q01362 / membrane spanning 4-domains A2  / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / complex / reaction
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000165458 INPPL1 / O15357 / inositol polyphosphate phosphatase like 1  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000168918 INPP5D / Q92835 / inositol polyphosphate-5-phosphatase D  / complex / reaction
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / reaction / complex
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / complex / reaction
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000254647 INS / P01308 / insulin  / complex / reaction
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / complex / reaction
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex / reaction
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex / reaction
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000171105 INSR / P06213 / insulin receptor  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / complex / reaction
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex / reaction
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / complex / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / complex / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000167244 IGF2 / P01344 / insulin like growth factor 2  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / complex / reaction
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / complex / reaction
 ENSG00000179639 FCER1A / P12319 / Fc fragment of IgE receptor Ia  / reaction
 ENSG00000211891 IGHE / P01854 / immunoglobulin heavy constant epsilon  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction






 

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