Manteia

ENSG00000103653

Homo sapiens

Features

Gene ID:	ENSG00000103653

Biological name :	CSK

Synonyms :	CSK / C-terminal Src kinase / P41240

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	15
Strand:	1
Band:	q24.1
Gene start:	74782057
Gene end:	74803198

Corresponding Affymetrix probe sets:	202329_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000457497 Ensembl peptide - ENSP00000454906 Ensembl peptide - ENSP00000457714 Ensembl peptide - ENSP00000220003 Ensembl peptide - ENSP00000414764 Ensembl peptide - ENSP00000454640 NCBI entrez gene - 1445 See in Manteia. OMIM - 124095 RefSeq - XM_017021925 RefSeq - NM_001127190 RefSeq - NM_001354988 RefSeq - NM_004383 RefSeq - XM_005254165 RefSeq Peptide - NP_001341917 RefSeq Peptide - NP_001120662 RefSeq Peptide - NP_004374 swissprot - H3BU69 swissprot - H3BUM9 swissprot - H3BN15 swissprot - B2R6Q4 swissprot - P41240 Ensembl - ENSG00000103653

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
csk	ENSDARG00000067996	Danio rerio
CSK	ENSGALG00000031270	Gallus gallus
Csk	ENSMUSG00000032312	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
MATK / P42679 / megakaryocyte-associated tyrosine kinase	ENSG00000007264	52
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase	ENSG00000097007	40
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase	ENSG00000143322	40
TEC / P42680 / tec protein tyrosine kinase	ENSG00000135605	37
TXK / P42681 / TXK tyrosine kinase	ENSG00000074966	36
BTK / Q06187 / Bruton tyrosine kinase	ENSG00000010671	35
BMX / P51813 / BMX non-receptor tyrosine kinase	ENSG00000102010	34
FER / P16591 / FER tyrosine kinase	ENSG00000151422	34
FES / P07332 / FES proto-oncogene, tyrosine kinase	ENSG00000182511	34
ITK / Q08881 / IL2 inducible T cell kinase	ENSG00000113263	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001452	SH3 domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR035026	Tyrosine-protein kinase CSK
IPR035027	CSK-like, SH2 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001817	regulation of cytokine production	IBA
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006468	protein phosphorylation	TAS
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	TAS
biological_process	GO:0007417	central nervous system development	IBA
biological_process	GO:0007420	brain development	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0032715	negative regulation of interleukin-6 production	IEA
biological_process	GO:0033673	negative regulation of kinase activity	IEA
biological_process	GO:0034332	adherens junction organization	IBA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042997	negative regulation of Golgi to plasma membrane protein transport	IDA
biological_process	GO:0043406	positive regulation of MAP kinase activity	IEA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045779	negative regulation of bone resorption	IEA
biological_process	GO:0046777	protein autophosphorylation	IEA
biological_process	GO:0048709	oligodendrocyte differentiation	IEA
biological_process	GO:0050765	negative regulation of phagocytosis	IEA
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	IBA
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IEA
biological_process	GO:0071375	cellular response to peptide hormone stimulus	IEA
cellular_component	GO:0005737	cytoplasm	TAS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005911	cell-cell junction	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
cellular_component	GO:0045121	membrane raft	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008022	protein C-terminus binding	TAS
molecular_function	GO:0016301	kinase activity	TAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019903	protein phosphatase binding	IEA
molecular_function	GO:0034236	protein kinase A catalytic subunit binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0070064	proline-rich region binding	IEA

Pathways (from Reactome)

Pathway description

GAB1 signalosome

Phosphorylation of CD3 and TCR zeta chains

Integrin alphaIIb beta3 signaling

PD-1 signaling

MAP2K and MAPK activation

Signaling by moderate kinase activity BRAF mutants

Signaling by high-kinase activity BRAF mutants

Signaling by RAS mutants

Signaling by BRAF and RAF fusions

Paradoxical activation of RAF signaling by kinase inactive BRAF

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000035403	VCL / P18206 / vinculin	/ complex
ENSG00000010610	CD4 / P01730 / CD4 molecule	/ reaction
ENSG00000089159	PXN / P49023 / paxillin	/ complex
ENSG00000076641	PAG1 / Q9NWQ8 / phosphoprotein membrane anchor with glycosphingolipid microdomains 1	/ complex / reaction
ENSG00000103653	CSK / P41240 / C-terminal Src kinase	/ complex / reaction
ENSG00000127314	RAP1B / P61224 / RAP1B, member of RAS oncogene family	/ complex / reaction
ENSG00000110799	VWF / P04275 / von Willebrand factor	/ reaction / complex
ENSG00000005961	ITGA2B / P08514 / integrin subunit alpha 2b	/ complex / reaction
ENSG00000171560	FGA / P02671 / fibrinogen alpha chain	/ reaction / complex
ENSG00000167286	CD3D / P04234 / CD3d molecule	/ reaction
ENSG00000171564	FGB / P02675 / fibrinogen beta chain	/ reaction / complex
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ reaction
ENSG00000115414	FN1 / P02751 / fibronectin 1	/ reaction / complex
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ reaction
ENSG00000188389	PDCD1 / Q15116 / programmed cell death 1	/ reaction / complex
ENSG00000137076	TLN1 / Q9Y490 / talin 1	/ complex / reaction
ENSG00000171557	FGG / P02679 / fibrinogen gamma chain	/ reaction / complex
ENSG00000196735	P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	/ reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ reaction
ENSG00000116473	RAP1A / P62834 / RAP1A, member of RAS oncogene family	/ complex / reaction
ENSG00000077420	Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein	/ complex / reaction
ENSG00000198851	CD3E / P07766 / CD3e molecule	/ reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000204287	P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha	/ reaction
ENSG00000237541	P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	/ reaction
ENSG00000211799	TRAV19 / T cell receptor alpha variable 19	/ reaction
ENSG00000120217	CD274 / Q9NZQ7 / CD274 molecule	/ reaction / complex
ENSG00000197646	Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2	/ reaction / complex
ENSG00000231389	P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	/ reaction
ENSG00000259207	ITGB3 / P05106 / integrin subunit beta 3	/ complex / reaction
ENSG00000111679	PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6	/ complex / reaction
ENSG00000179295	PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	/ complex / reaction
ENSG00000134242	PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22	/ complex
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr