ENSG00000160654


Homo sapiens

Features
Gene ID: ENSG00000160654
  
Biological name :CD3G
  
Synonyms : CD3G / CD3g molecule / P09693
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 118344344
Gene end: 118355161
  
Corresponding Affymetrix probe sets: 206804_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000292144
Ensembl peptide - ENSP00000431445
Ensembl peptide - ENSP00000376621
NCBI entrez gene - 917     See in Manteia.
OMIM - 186740
RefSeq - NM_000073
RefSeq - XM_006718941
RefSeq - XM_005271724
RefSeq Peptide - NP_000064
swissprot - B0YIY5
swissprot - P09693
swissprot - J3KNA5
swissprot - A8MUH3
Ensembl - ENSG00000160654
  
Related genetic diseases (OMIM): 615607 - Immunodeficiency 17, CD3 gamma deficient, 615607
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD3DENSGALG00000007418Gallus gallus
 Cd3gENSMUSG00000002033Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CD3D / P04234 / CD3d moleculeENSG0000016728637


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR003598  Immunoglobulin subtype 2
 IPR013783  Immunoglobulin-like fold
 IPR015484  CD3 protein, epsilon/gamma/delta subunit
 IPR032052  CD3 gamma/delta subunit, Ig-like domain
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0015031 protein transport IMP
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0065003 protein-containing complex assembly NAS
 biological_processGO:0070228 regulation of lymphocyte apoptotic process IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0042101 T cell receptor complex NAS
 cellular_componentGO:0042105 alpha-beta T cell receptor complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity NAS
 molecular_functionGO:0042608 T cell receptor binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
PD-1 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000403 Recurrent otitis media 
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 HP:0000964 Eczema "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." [HPO:curators]
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 HP:0001508 Failure to thrive 
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 HP:0001890 Autoimmune hemolytic anemia 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002242 Abnormality of the intestines 
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 HP:0002721 Immunodeficiency 
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 HP:0003828 Variable expressivity 
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 HP:0005415 Decreased number of CD8+ T cells 
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 HP:0031123 Recurrent gastroenteritis "Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis." []
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / complex / reaction
 ENSG00000158477 CD1A / P06126 / CD1a molecule  / complex / reaction
 ENSG00000153563 CD8A / P01732 / CD8a molecule  / complex
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction / complex
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000158473 CD1D / P15813 / CD1d molecule  / complex / reaction
 ENSG00000158485 CD1B / P29016 / CD1b molecule  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000158481 CD1C / P29017 / CD1c molecule  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000172116 CD8B / P10966 / CD8b molecule  / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000134242 PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22  / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex
 ENSG00000149177 PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J  / reaction






 

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