ENSG00000145675


Homo sapiens

Features
Gene ID: ENSG00000145675
  
Biological name :PIK3R1
  
Synonyms : P27986 / phosphoinositide-3-kinase regulatory subunit 1 / PIK3R1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.1
Gene start: 68215720
Gene end: 68301821
  
Corresponding Affymetrix probe sets: 212239_at (Human Genome U133 Plus 2.0 Array)   212240_s_at (Human Genome U133 Plus 2.0 Array)   212249_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429277
Ensembl peptide - ENSP00000429766
Ensembl peptide - ENSP00000431058
Ensembl peptide - ENSP00000430424
Ensembl peptide - ENSP00000430126
Ensembl peptide - ENSP00000430098
Ensembl peptide - ENSP00000323512
Ensembl peptide - ENSP00000338554
Ensembl peptide - ENSP00000428056
Ensembl peptide - ENSP00000428566
Ensembl peptide - ENSP00000429156
NCBI entrez gene - 5295     See in Manteia.
OMIM - 171833
RefSeq - XM_017009586
RefSeq - NM_001242466
RefSeq - NM_181504
RefSeq - NM_181523
RefSeq - NM_181524
RefSeq - XM_005248542
RefSeq - XM_011543493
RefSeq - XM_017009585
RefSeq Peptide - NP_852556
RefSeq Peptide - NP_001229395
RefSeq Peptide - NP_852664
RefSeq Peptide - NP_852665
swissprot - E5RGI8
swissprot - H0YB27
swissprot - H0YBC2
swissprot - E5RHI0
swissprot - E5RK66
swissprot - E5RJY0
swissprot - P27986
Ensembl - ENSG00000145675
  
Related genetic diseases (OMIM): 269880 - SHORT syndrome, 269880
  615214 - ?Agammaglobulinemia 7, autosomal recessive, 615214
  616005 - Immunodeficiency 36, 616005
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r1ENSDARG00000038524Danio rerio
 PIK3R1ENSGALG00000014786Gallus gallus
 P26450ENSMUSG00000041417Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2ENSG0000010564758
AC007192.1ENSG0000026817358
AL358075.4ENSG0000027813948
PIK3R3 / Q92569 / phosphoinositide-3-kinase regulatory subunit 3ENSG0000011746147


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR001720  PI3K p85/p55 subunit
 IPR008936  Rho GTPase activation protein
 IPR032498  PI3K p85 subunit, inter-SH2 domain
 IPR035020  PI3K p85 subunit, C-terminal SH2 domain
 IPR035022  PI3K p85 subunit, N-terminal SH2 domain
 IPR035591  Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis ISS
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0033120 positive regulation of RNA splicing IMP
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046326 positive regulation of glucose import ISS
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation ISS
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IDA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling TAS
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISS
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex ISS
 cellular_componentGO:0005943 phosphatidylinositol 3-kinase complex, class IA ISS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:1990578 perinuclear endoplasmic reticulum membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity ISS
 molecular_functionGO:0005158 insulin receptor binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity ISS
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA
 molecular_functionGO:0043125 ErbB-3 class receptor binding IDA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISS
 molecular_functionGO:0043559 insulin binding IDA
 molecular_functionGO:0043560 insulin receptor substrate binding ISS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Aberrant PI3K in Cancer
Costimulation by the CD28 family
Downstream TCR signaling
Downstream signal transduction
GPVI-mediated activation cascade
GP1b-IX-V activation signalling
GAB1 signalosome
Interleukin receptor SHC signaling
IRS-mediated signalling
MET activates PI3K/AKT signaling
Nephrin family interactions
PI-3K cascade:FGFR2
PIP3 activates AKT signaling
PI3K events in ERBB2 signaling
RET signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
Regulation of signaling by CBL
Signaling by FGFR3 point mutants in cancer
Signaling by FGFR3 fusions in cancer
Signaling by SCF-KIT
Tie2 Signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-7 signaling
G alpha (q) signalling events
Activated NTRK3 signals through PI3K
Interleukin-3, Interleukin-5 and GM-CSF signaling
G alpha (12/13) signalling events
PI3K Cascade
Signaling by FGFR1 in disease
VEGFA-VEGFR2 Pathway
PI-3K cascade:FGFR4
Synthesis of PIPs at the plasma membrane
CD28 dependent PI3K/Akt signaling
PI-3K cascade:FGFR1
DAP12 signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR4 in disease
Signaling by FGFR2 in disease
PI-3K cascade:FGFR3
PI3K/AKT activation
Signaling by cytosolic FGFR1 fusion mutants
PI3K events in ERBB4 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Activated NTRK2 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000023 Inguinal hernia 
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 HP:0000218 High palate "Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective)." [pmid:19125428]
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 HP:0000246 Sinusitis 
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 HP:0000272 Malar hypoplasia "Underdeveloped midface region." [HPO:curators]
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 HP:0000277 Abnormality of the mandible "Any abnormality of the mandible, the bone of the lower jaw." [HPO:curators]
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 HP:0000286 Epicanthus "An epicanthal fold is a semilunar fold of skin that extends from the upper eyelid across the medial canthal area to the lower eyelid." [HPO:curators]
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 HP:0000316 Hypertelorism 
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 HP:0000325 Triangular facies 
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 HP:0000336 Prominent supraorbital ridges "Abnormal prominence of the supraorbital ridges, which are bony ridge located above the eye sockets in the area of the eyebrows." [HPO:curators]
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 HP:0000347 Mandibular hypoplasia "Underdevelopment of the mandible." [HPO:curators]
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 HP:0000389 Chronic otitis media 
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 HP:0000400 Large ears 
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 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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 HP:0000430 Hypoplastic nasal alae "Thinned, deficient, or excessively arched `ala nasi` (FMA:59519)." [pmid:19152422]
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 HP:0000431 Broad nasal bridge "Increased horizontal dimension of the upper, bony part of the nose." [HPO:curators]
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 HP:0000485 Megalocornea "An enlargement of the `cornea` (FMA:58238) with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age." [HPO:curators]
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 HP:0000490 Deep set eyes 
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 HP:0000501 Glaucoma "Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure." [HPO:curators]
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 HP:0000506 Telecanthus "An abnormally increased distance between the medial canthi (angle between eyelids) of the eyelids." [HPO:curators]
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 HP:0000509 Conjunctivitis "Inflammation of the conjunctiva." [HPO:curators]
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 HP:0000518 Cataract "A cataract is an opacity or clouding that develops in the crystalline `lens` (FMA:58241) of the eye or in its `capsule` (FMA:58881)." [HPO:probinson]
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 HP:0000545 Myopia 
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 HP:0000558 Rieger anomaly 
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 HP:0000593 Abnormality of the anterior chamber "Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris." [HPO:curators]
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 HP:0000615 Abnormality of the pupils 
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 HP:0000627 Posterior embryotoxon 
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 HP:0000668 Hypodontia "Hypodontia describes a situation when there are fewer than the normal number of teeth, whereby 6 teeth or fewer teeth are missing (oligodontia refers to the condition of missing more than 6 teeth and the congenital absence of all teeth is called anodontia)." [HPO:curators]
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 HP:0000682 Abnormality of dental enamel "An abnormality of the dental enamel, which is the external layer of the teeth, being a highly mineralized substance consisting primarily of hydroxylapatite." [HPO:curators]
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 HP:0000684 Delayed dentition "Delayed eruption of teeth." [HPO:curators]
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 HP:0000689 Dental malocclusion "Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns." [HPO:curators]
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 HP:0000691 Microdontia 
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 HP:0000750 Impaired language development 
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 HP:0000819 Diabetes mellitus 
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 HP:0000831 Insulin-resistant diabetes mellitus 
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 HP:0000833 Glucose intolerance 
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 HP:0000855 Insulin resistance 
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 HP:0000951 Abnormality of the skin "An abnormality of the `skin` (FMA:7163)." [HPO:probinson]
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 HP:0000963 Thin skin 
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 HP:0000988 Skin rash 
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 HP:0001006 Hypotrichosis "Reduced or lacking hair growth." [HPO:curators]
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 HP:0001156 Brachydactyly 
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 HP:0001287 Meningitis 
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 HP:0001369 Arthritis 
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 HP:0001388 Joint laxity 
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 HP:0001508 Failure to thrive 
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 HP:0001511 Intrauterine growth retardation 
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 HP:0001518 Low birth weight 
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 HP:0001581 Recurrent skin infections "Infections of the skin that happen multiple times." [HPO:curators]
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 HP:0001596 Alopecia "Loss of hair from the head or body." [HPO:curators]
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 HP:0001824 Weight loss 
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 HP:0001875 Neutropenia 
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 HP:0001944 Dehydration 
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 HP:0001945 Fever 
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 HP:0002007 Frontal bossing "The presence of an unusually prominent forehead." [HPO:curators]
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 HP:0002014 Diarrhea 
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 HP:0002024 Malabsorption 
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 HP:0002110 Bronchiectasis 
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 HP:0002167 Neurological speech impairment 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002714 Downturned corners of mouth "A morphological `abnormality of the mouth` (HP:0000153) in which the `angle of the mouth` (FMA:77269) is downturned." [HPO:probinson]
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 HP:0002715 Immunological abnormality 
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 HP:0002718 Recurrent bacterial infections 
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 HP:0002721 Immunodeficiency 
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 HP:0002750 Delayed skeletal maturation "A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body." [HPO:curators]
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 HP:0002754 Osteomyelitis 
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 HP:0003074 Hyperglycemia 
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 HP:0003510 Short stature, severe "A severe degree of short stature." [HPO:curators]
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 HP:0003561 Birth length <3rd percentile 
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 HP:0003593 Early onset 
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 HP:0004279 Hypoplastic hand 
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 HP:0004313 Reduced immunoglobulin levels 
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 HP:0004396 Poor appetite 
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 HP:0004432 Agammaglobulinemia 
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 HP:0005692 Joint hyperflexibility 
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 HP:0007392 Excessive wrinkled skin 
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 HP:0007676 Hypoplasia of the iris 
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 HP:0007957 Variable degree of corneal opacities 
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 HP:0008572 External ear malformation 
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 HP:0009125 Lipodystrophy "Degenerative changes of the fat tissue." [HPO:curators]
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 HP:0009466 Radial deviation of fingers 
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 HP:0010580 Enlarged epiphyses 
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 HP:0010751 Chin dimple "A persistent midline depression of the skin over the fat pad of the chin." [pmid:19125436]
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 HP:0011220 Prominent forehead "Forward prominence of the entire forehead, due to protrusion of the frontal bone." [pmid:19125436]
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 HP:0011800 Midface retrusion "Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle." [DDD:jclayton-smith]
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 HP:0012115 Hepatitis "Inflammation of the liver." [HPO:probinson]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0012735 Cough "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." [HPO:probinson]
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 HP:0030084 Clinodactyly "An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe)." [pmid:16252026]
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 HP:0100578 Lipoatrophy "Localized loss of fat tissue." [HPO:sdoelken]
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 HP:0100658 Cellulitis 
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 HP:0100678 Wrinkled skin 
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 HP:0100806 Sepsis 
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 HP:0200043 verrucae "Benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas." [HPO:SKOEHLER]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000113525 IL5 / P05113 / interleukin 5  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000128340 RAC2 / P15153 / Rac family small GTPase 2  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / complex
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000091181 IL5RA / Q01344 / interleukin 5 receptor subunit alpha  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000100368 CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit  / complex / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex
 ENSG00000164399 IL3 / P08700 / interleukin 3  / complex / reaction
 ENSG00000164400 CSF2 / P04141 / colony stimulating factor 2  / complex / reaction
 ENSG00000167601 AXL / P30530 / AXL receptor tyrosine kinase  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / complex / reaction
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000090554 FLT3LG / P49771 / fms related tyrosine kinase 3 ligand  / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / complex / reaction
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000130427 EPO / P01588 / erythropoietin  / complex / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / complex / reaction
 ENSG00000213809 KLRK1 / P26718 / killer cell lectin like receptor K1  / complex / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / complex / reaction
 ENSG00000122025 FLT3 / P36888 / fms related tyrosine kinase 3  / complex
 ENSG00000134962 KLB / Q86Z14 / klotho beta  / complex / reaction
 ENSG00000068078 FGFR3 / P22607 / fibroblast growth factor receptor 3  / complex / reaction
 ENSG00000121594 CD80 / P33681 / CD80 molecule  / complex / reaction
 ENSG00000114013 CD86 / P42081 / CD86 molecule  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex / reaction
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / complex / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / complex / reaction
 ENSG00000163519 TRAT1 / Q6PIZ9 / T cell receptor associated transmembrane adaptor 1  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000147475 ERLIN2 / O94905 / ER lipid raft associated 2  / complex / reaction
 ENSG00000169704 GP9 / P14770 / glycoprotein IX platelet  / complex / reaction
 ENSG00000160867 FGFR4 / P22455 / fibroblast growth factor receptor 4  / complex / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000186716 BCR / P11274 / BCR, RhoGEF and GTPase activating protein  / complex / reaction
 ENSG00000162344 FGF19 / O95750 / fibroblast growth factor 19  / complex / reaction
 ENSG00000086730 LAT2 / Q9GZY6 / linker for activation of T cells family member 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / complex / reaction
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000095970 TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2  / complex / reaction
 ENSG00000185245 GP1BA / P07359 / glycoprotein Ib platelet alpha subunit  / complex / reaction
 ENSG00000163600 ICOS / Q9Y6W8 / inducible T cell costimulator  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000177455 CD19 / P15391 / CD19 molecule  / complex / reaction
 ENSG00000134539 KLRD1 / Q13241 / killer cell lectin like receptor D1  / complex / reaction
 ENSG00000185291 IL3RA / P26951 / interleukin 3 receptor subunit alpha  / reaction / complex
 ENSG00000155629 Q6ZUJ8 / PIK3AP1 / phosphoinositide-3-kinase adaptor protein 1  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex
 ENSG00000033327 GAB2 / Q9UQC2 / GRB2 associated binding protein 2  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000198223 CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000177105 RHOG / P84095 / ras homolog family member G  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex / reaction
 ENSG00000203618 GP1BB / P13224 / glycoprotein Ib platelet beta subunit  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000205809 KLRC2 / P26717 / killer cell lectin like receptor C2  / complex / reaction
 ENSG00000133116 KL / klotho / Q9UEF7  / complex / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000178732 GP5 / P40197 / glycoprotein V platelet  / complex / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / complex / reaction
 ENSG00000166225 FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000225950 NTF4 / P34130 / neurotrophin 4  / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000198087 CD2AP / Q9Y5K6 / CD2 associated protein  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000027869 Q9NP31 / SH2D2A / SH2 domain containing 2A  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction






 

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