ENSG00000211896


Homo sapiens

Features
Gene ID: ENSG00000211896
  
Biological name :IGHG1
  
Synonyms : IGHG1 / immunoglobulin heavy constant gamma 1 (G1m marker) / P01857
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 105736343
Gene end: 105743071
  
Corresponding Affymetrix probe sets: 211430_s_at (Human Genome U133 Plus 2.0 Array)   228518_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000374984
Ensembl peptide - ENSP00000374990
Ensembl peptide - ENSP00000374991
swissprot - A0A0A0MS07
swissprot - A0A0A0MS08
swissprot - P01857
Ensembl - ENSG00000211896
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighv1-4ENSDARG00000096355Danio rerio
 Ighg1ENSMUSG00000076614Mus musculus
 Ighg2bENSMUSG00000076613Mus musculus
 Ighg2cENSMUSG00000076612Mus musculus
 Ighg3ENSMUSG00000076615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGHG3 / immunoglobulin heavy constant gamma 3 (G3m marker)ENSG0000021189793
IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)ENSG0000021189289
IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)ENSG0000021189387
IGHE / P01854 / immunoglobulin heavy constant epsilonENSG0000021189133
IGHM / P01871 / immunoglobulin heavy constant muENSG0000021189929
IGHA2 / P01877 / immunoglobulin heavy constant alpha 2 (A2m marker)ENSG0000021189026
IGHA1 / P01876 / immunoglobulin heavy constant alpha 1ENSG0000021189526


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006910 phagocytosis, recognition IBA
 biological_processGO:0006911 phagocytosis, engulfment IBA
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0006958 complement activation, classical pathway IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050871 positive regulation of B cell activation IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042571 immunoglobulin complex, circulating IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003823 antigen binding TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0034987 immunoglobulin receptor binding IBA


Pathways (from Reactome)
Pathway description
Initial triggering of complement
Classical antibody-mediated complement activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interleukin-4 and Interleukin-13 signaling
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149131 P05155 / SERPING1 / serpin family G member 1  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000182326 C1S / P09871 / complement C1s  / complex
 ENSG00000173369 C1QB / P02746 / complement C1q B chain  / complex
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000159189 C1QC / P02747 / complement C1q C chain  / complex
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000173372 C1QA / P02745 / complement C1q A chain  / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000166278 C2 / P06681 / complement C2  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex
 ENSG00000224389 C4B / P0C0L5 / complement C4B (Chido blood group)  / reaction
 ENSG00000244731 C4A / P0C0L4 / complement C4A (Rodgers blood group)  / reaction
 ENSG00000159403 C1R / P00736 / complement C1r  / complex
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex






 

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