ENSG00000134215


Homo sapiens

Features
Gene ID: ENSG00000134215
  
Biological name :VAV3
  
Synonyms : Q9UKW4 / VAV3 / vav guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.3
Gene start: 107571160
Gene end: 107965144
  
Corresponding Affymetrix probe sets: 218806_s_at (Human Genome U133 Plus 2.0 Array)   218807_at (Human Genome U133 Plus 2.0 Array)   224221_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433559
Ensembl peptide - ENSP00000432865
Ensembl peptide - ENSP00000434944
Ensembl peptide - ENSP00000359073
Ensembl peptide - ENSP00000394897
Ensembl peptide - ENSP00000431544
Ensembl peptide - ENSP00000432540
NCBI entrez gene - 10451     See in Manteia.
OMIM - 605541
RefSeq - XM_017000056
RefSeq - NM_006113
RefSeq - XM_005270360
RefSeq - XM_005270361
RefSeq - XM_017000053
RefSeq - XM_017000054
RefSeq - XM_017000055
RefSeq - NM_001079874
RefSeq Peptide - NP_001073343
RefSeq Peptide - NP_006104
swissprot - H0YCG7
swissprot - H0YDG2
swissprot - Q9UKW4
swissprot - E9PMJ5
Ensembl - ENSG00000134215
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vav3bENSDARG00000075962Danio rerio
 VAV3ENSGALG00000039327Gallus gallus
 Vav3ENSMUSG00000033721Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG0000014196859
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG0000016029354
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG0000012412618
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG0000004688916
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG0000014642616
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG0000015629915
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295714
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG0000010260613
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG0000012967513
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG0000013600212
AL359736.1ENSG0000027316712
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG0000013108910


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000980  SH2 domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003096  Smooth muscle protein/calponin
 IPR011993  PH-like domain superfamily
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR035734  VAV3 protein, second SH3 domain
 IPR035881  VAV3, SH2 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006906 vesicle fusion IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0008361 regulation of cell size IGI
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030031 cell projection assembly IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity IGI
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000143226 FCGR2A / P12318 / Fc fragment of IgG receptor IIa  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / complex / reaction
 ENSG00000177105 RHOG / P84095 / ras homolog family member G  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / reaction / complex
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000203747 FCGR3A / P08637 / Fc fragment of IgG receptor IIIa  / complex / reaction
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction






 

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