Manteia

ENSG00000180370

Homo sapiens

Features

Gene ID:	ENSG00000180370

Biological name :	PAK2

Synonyms :	p21 (RAC1) activated kinase 2 / PAK2 / Q13177

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	3
Strand:	1
Band:	q29
Gene start:	196739857
Gene end:	196832647

Corresponding Affymetrix probe sets:	1559052_s_at (Human Genome U133 Plus 2.0 Array) 205962_at (Human Genome U133 Plus 2.0 Array) 208875_s_at (Human Genome U133 Plus 2.0 Array) 208876_s_at (Human Genome U133 Plus 2.0 Array) 208877_at (Human Genome U133 Plus 2.0 Array) 208878_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000314067 Ensembl peptide - ENSP00000402927 NCBI entrez gene - 5062 See in Manteia. OMIM - 605022 RefSeq - XM_017006501 RefSeq - NM_002577 RefSeq - XM_011512870 RefSeq Peptide - NP_002568 swissprot - Q13177 swissprot - H7C1X3 Ensembl - ENSG00000180370

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pak2a	ENSDARG00000068177	Danio rerio
pak2b	ENSDARG00000018476	Danio rerio
PAK2	ENSGALG00000006426	Gallus gallus
Pak2	ENSMUSG00000022781	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PAK3 / O75914 / p21 (RAC1) activated kinase 3	ENSG00000077264	77
PAK1 / Q13153 / p21 (RAC1) activated kinase 1	ENSG00000149269	75
PAK5 / Q9P286 / p21 (RAC1) activated kinase 5	ENSG00000101349	37
PAK4 / O96013 / p21 (RAC1) activated kinase 4	ENSG00000130669	37
PAK6 / Q9NQU5 / p21 (RAC1) activated kinase 6	ENSG00000137843	36
BUB1B-PAK6 / BUB1B-PAK6 readthrough	ENSG00000259288	36
TAOK2 / Q9UL54 / TAO kinase 2	ENSG00000149930	23
TAOK1 / Q7L7X3 / TAO kinase 1	ENSG00000160551	23
TAOK3 / Q9H2K8 / TAO kinase 3	ENSG00000135090	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR000095	CRIB domain
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR033923	p21 activated kinase binding domain
IPR035064	p21-activated kinase 2, catalytic domain
IPR035065	Serine/threonine-protein kinase PAK2/3
IPR036936	CRIB domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0006469	negative regulation of protein kinase activity	TAS
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007266	Rho protein signal transduction	IBA
biological_process	GO:0007346	regulation of mitotic cell cycle	IBA
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0016477	cell migration	IBA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IDA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IBA
biological_process	GO:0030036	actin cytoskeleton organization	IBA
biological_process	GO:0031098	stress-activated protein kinase signaling cascade	IBA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0035722	interleukin-12-mediated signaling pathway	TAS
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0040008	regulation of growth	IEA
biological_process	GO:0042981	regulation of apoptotic process	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0043408	regulation of MAPK cascade	IBA
biological_process	GO:0046777	protein autophosphorylation	IDA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0050690	regulation of defense response to virus by virus	TAS
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0060996	dendritic spine development	IEA
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
biological_process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP
biological_process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019901	protein kinase binding	IPI
molecular_function	GO:0030296	protein tyrosine kinase activator activity	IDA
molecular_function	GO:0031267	small GTPase binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0045296	cadherin binding	IDA
molecular_function	GO:0048365	Rac GTPase binding	IPI

Pathways (from Reactome)

Pathway description

Nef and signal transduction

Generation of second messenger molecules

Regulation of PAK-2p34 activity by PS-GAP/RHG10

Regulation of activated PAK-2p34 by proteasome mediated degradation

Stimulation of the cell death response by PAK-2p34

FCERI mediated MAPK activation

CD28 dependent Vav1 pathway

Ephrin signaling

Sema3A PAK dependent Axon repulsion

Activation of RAC1

VEGFA-VEGFR2 Pathway

Smooth Muscle Contraction

VEGFR2 mediated vascular permeability

CD209 (DC-SIGN) signaling

RHO GTPases activate PAKs

MAPK6/MAPK4 signaling

Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000071051	NCK2 / O43639 / NCK adaptor protein 2	/ complex / reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ complex / reaction
ENSG00000077264	PAK3 / O75914 / p21 (RAC1) activated kinase 3	/ reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000075213	Q14563 / SEMA3A / semaphorin 3A	/ complex / reaction
ENSG00000099250	NRP1 / O14786 / neuropilin 1	/ complex / reaction
ENSG00000158092	NCK1 / P16333 / NCK adaptor protein 1	/ complex / reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000149269	PAK1 / Q13153 / p21 (RAC1) activated kinase 1	/ reaction
ENSG00000164305	CASP3 / P42574 / caspase 3	/ reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ complex / reaction
ENSG00000182511	FES / P07332 / FES proto-oncogene, tyrosine kinase	/ complex / reaction
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ complex / reaction
ENSG00000221866	PLXNA4 / Q9HCM2 / plexin A4	/ complex / reaction
ENSG00000100345	MYH9 / P35579 / myosin heavy chain 9	/ reaction
ENSG00000132155	RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase	/ reaction
ENSG00000118680	MYL12B / O14950 / myosin light chain 12B	/ reaction
ENSG00000069956	MAPK6 / Q16659 / mitogen-activated protein kinase 6	/ reaction
ENSG00000105357	MYH14 / Q7Z406 / myosin heavy chain 14	/ reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ reaction
ENSG00000101335	MYL9 / P24844 / myosin light chain 9	/ reaction
ENSG00000092841	MYL6 / P60660 / myosin light chain 6	/ reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000044115	CTNNA1 / P35221 / catenin alpha 1	/ reaction
ENSG00000133392	MYH11 / P35749 / myosin heavy chain 11	/ reaction
ENSG00000085733	CTTN / Q14247 / cortactin	/ reaction
ENSG00000173801	JUP / P14923 / junction plakoglobin	/ reaction
ENSG00000133026	MYH10 / P35580 / myosin heavy chain 10	/ reaction
ENSG00000179776	CDH5 / P33151 / cadherin 5	/ reaction
ENSG00000106683	LIMK1 / P53667 / LIM domain kinase 1	/ reaction
ENSG00000180370	PAK2 / Q13177 / p21 (RAC1) activated kinase 2	/ complex / reaction
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000065534	MYLK / Q15746 / myosin light chain kinase	/ reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000198561	CTNND1 / O60716 / catenin delta 1	/ reaction
ENSG00000076356	O75051 / PLXNA2 / plexin A2	/ reaction / complex
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction
ENSG00000130827	P51805 / PLXNA3 / plexin A3	/ reaction / complex
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000141639	MAPK4 / P31152 / mitogen-activated protein kinase 4	/ reaction
ENSG00000114554	PLXNA1 / Q9UIW2 / plexin A1	/ reaction / complex
ENSG00000071205	A1A4S6 / ARHGAP10 / Rho GTPase activating protein 10	/ complex / reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ complex / reaction
ENSG00000213658	LAT / O43561 / linker for activation of T cells	/ complex / reaction
ENSG00000197943	PLCG2 / P16885 / phospholipase C gamma 2	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr