Manteia

ENSG00000158092

Homo sapiens

Features

Gene ID:	ENSG00000158092

Biological name :	NCK1

Synonyms :	NCK1 / NCK adaptor protein 1 / P16333

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	3
Strand:	1
Band:	q22.3
Gene start:	136862208
Gene end:	136949823

Corresponding Affymetrix probe sets:	204725_s_at (Human Genome U133 Plus 2.0 Array) 211063_s_at (Human Genome U133 Plus 2.0 Array) 229895_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000417273 Ensembl peptide - ENSP00000419677 Ensembl peptide - ENSP00000419631 Ensembl peptide - ENSP00000419544 Ensembl peptide - ENSP00000419302 Ensembl peptide - ENSP00000418513 Ensembl peptide - ENSP00000418060 Ensembl peptide - ENSP00000417729 Ensembl peptide - ENSP00000288986 NCBI entrez gene - 4690 See in Manteia. OMIM - 600508 RefSeq - NM_001291999 RefSeq - NM_006153 RefSeq - NM_001190796 RefSeq Peptide - NP_001177725 RefSeq Peptide - NP_001278928 RefSeq Peptide - NP_006144 swissprot - C9K098 swissprot - P16333 swissprot - C9JVV5 swissprot - C9JAB9 swissprot - C9J869 swissprot - C9J0K5 swissprot - A0A0S2Z4Y3 swissprot - H7C5C7 Ensembl - ENSG00000158092

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nck1a	ENSDARG00000074262	Danio rerio
nck1b	ENSDARG00000075369	Danio rerio
Nck1	ENSMUSG00000032475	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
NCK2 / O43639 / NCK adaptor protein 2	ENSG00000071051	69
GRAP2 / O75791 / GRB2-related adaptor protein 2	ENSG00000100351	15
GRAP / Q13588 / GRB2-related adaptor protein	ENSG00000154016	15
GRB2 / P62993 / growth factor receptor bound protein 2	ENSG00000177885	14
GRAPL / Q8TC17 / GRB2 related adaptor protein like	ENSG00000189152	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR001452	SH3 domain
IPR017304	Cytoplasmic protein NCK
IPR035562	Nck1, SH3 domain 1
IPR035564	Nck1, SH3 domain 2
IPR035565	Nck1, SH3 domain 3
IPR035882	Nck1, SH2 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006417	regulation of translation	IEA
biological_process	GO:0006469	negative regulation of protein kinase activity	IEA
biological_process	GO:0006930	substrate-dependent cell migration, cell extension	IEA
biological_process	GO:0007015	actin filament organization	IEA
biological_process	GO:0007172	signal complex assembly	NAS
biological_process	GO:0010976	positive regulation of neuron projection development	IEA
biological_process	GO:0016477	cell migration	IEA
biological_process	GO:0030032	lamellipodium assembly	IEA
biological_process	GO:0030334	regulation of cell migration	IEA
biological_process	GO:0030838	positive regulation of actin filament polymerization	IMP
biological_process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	IDA
biological_process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IDA
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042102	positive regulation of T cell proliferation	IMP
biological_process	GO:0042110	T cell activation	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	IMP
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0048013	ephrin receptor signaling pathway	IEA
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0051707	response to other organism	IEA
biological_process	GO:0060548	negative regulation of cell death	IDA
biological_process	GO:0070262	peptidyl-serine dephosphorylation	IDA
biological_process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA
biological_process	GO:1903676	positive regulation of cap-dependent translational initiation	IDA
biological_process	GO:1903679	positive regulation of cap-independent translational initiation	IDA
biological_process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IDA
biological_process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IDA
biological_process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IDA
cellular_component	GO:0000164	protein phosphatase type 1 complex	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	TAS
cellular_component	GO:0005783	endoplasmic reticulum	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005840	ribosome	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005911	cell-cell junction	IEA
cellular_component	GO:0012506	vesicle membrane	IEA
molecular_function	GO:0004860	protein kinase inhibitor activity	IDA
molecular_function	GO:0005070	SH3/SH2 adaptor activity	NAS
molecular_function	GO:0005102	signaling receptor binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008093	cytoskeletal adaptor activity	NAS
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0030159	receptor signaling complex scaffold activity	NAS
molecular_function	GO:0030674	protein binding, bridging	IC
molecular_function	GO:0030971	receptor tyrosine kinase binding	IPI
molecular_function	GO:0045296	cadherin binding	IDA
molecular_function	GO:0046875	ephrin receptor binding	IEA
molecular_function	GO:0060090	molecular adaptor activity	IPI
molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	IPI

Pathways (from Reactome)

Pathway description

Downstream signal transduction

Generation of second messenger molecules

Regulation of actin dynamics for phagocytic cup formation

Nephrin family interactions

DCC mediated attractive signaling

Activation of RAC1

VEGFA-VEGFR2 Pathway

RHO GTPases Activate WASPs and WAVEs

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ complex / reaction
ENSG00000065320	NTN1 / O95631 / netrin 1	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000106299	WASL / O00401 / Wiskott-Aldrich syndrome like	/ complex / reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ complex / reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000134853	P16234 / PDGFRA / platelet derived growth factor receptor alpha	/ complex / reaction
ENSG00000113721	P09619 / PDGFRB / platelet derived growth factor receptor beta	/ complex / reaction
ENSG00000100485	SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000122574	WIPF3 / A6NGB9 / WAS/WASL interacting protein family member 3	/ reaction
ENSG00000077264	PAK3 / O75914 / p21 (RAC1) activated kinase 3	/ complex / reaction
ENSG00000149269	PAK1 / Q13153 / p21 (RAC1) activated kinase 1	/ complex / reaction
ENSG00000150760	DOCK1 / Q14185 / dedicator of cytokinesis 1	/ complex / reaction
ENSG00000173210	ABLIM3 / O94929 / actin binding LIM protein family member 3	/ complex / reaction
ENSG00000099204	ABLIM1 / O14639 / actin binding LIM protein 1	/ complex / reaction
ENSG00000115935	WIPF1 / O43516 / WAS/WASL interacting protein family member 1	/ reaction
ENSG00000038382	TRIO / O75962 / trio Rho guanine nucleotide exchange factor	/ complex / reaction
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ complex / reaction
ENSG00000163995	ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2	/ complex / reaction
ENSG00000180370	PAK2 / Q13177 / p21 (RAC1) activated kinase 2	/ complex / reaction
ENSG00000171475	WIPF2 / Q8TF74 / WAS/WASL interacting protein family member 2	/ reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000015285	WAS / P42768 / Wiskott-Aldrich syndrome	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000187323	DCC / P43146 / DCC netrin 1 receptor	/ complex / reaction
ENSG00000145147	SLIT2 / O94813 / slit guidance ligand 2	/ complex / reaction
ENSG00000169398	PTK2 / Q05397 / protein tyrosine kinase 2	/ complex / reaction
ENSG00000100311	PDGFB / P01127 / platelet derived growth factor subunit B	/ complex / reaction
ENSG00000197461	PDGFA / P04085 / platelet derived growth factor subunit A	/ complex / reaction
ENSG00000161270	NPHS1 / O60500 / NPHS1, nephrin	/ complex / reaction
ENSG00000183853	Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000169855	ROBO1 / Q9Y6N7 / roundabout guidance receptor 1	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr