ENSG00000197461


Homo sapiens

Features
Gene ID: ENSG00000197461
  
Biological name :PDGFA
  
Synonyms : P04085 / PDGFA / platelet derived growth factor subunit A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.3
Gene start: 497258
Gene end: 520296
  
Corresponding Affymetrix probe sets: 205463_s_at (Human Genome U133 Plus 2.0 Array)   216867_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384673
Ensembl peptide - ENSP00000346508
Ensembl peptide - ENSP00000383572
Ensembl peptide - ENSP00000383889
NCBI entrez gene - 5154     See in Manteia.
OMIM - 173430
RefSeq - XM_017012289
RefSeq - XM_011515415
RefSeq - XM_011515416
RefSeq - XM_011515417
RefSeq - XM_011515418
RefSeq - XM_011515419
RefSeq - NM_002607
RefSeq - NM_033023
RefSeq Peptide - NP_002598
RefSeq Peptide - NP_148983
swissprot - H7BYW6
swissprot - P04085
swissprot - A0A0A0MSC4
Ensembl - ENSG00000197461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfaaENSDARG00000110069Danio rerio
 pdgfaaENSDARG00000109371Danio rerio
 pdgfabENSDARG00000098578Danio rerio
 PDGFAENSGALG00000003642Gallus gallus
 PdgfaENSMUSG00000025856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFB / P01127 / platelet derived growth factor subunit BENSG0000010031141


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001775 cell activation TAS
 biological_processGO:0001942 hair follicle development ISS
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation ISS
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009887 animal organ morphogenesis ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010512 negative regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0010544 negative regulation of platelet activation IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014910 regulation of smooth muscle cell migration IDA
 biological_processGO:0030031 cell projection assembly ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization TAS
 biological_processGO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IDA
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043588 skin development ISS
 biological_processGO:0045740 positive regulation of DNA replication IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048286 lung alveolus development ISS
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050919 negative chemotaxis IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060683 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1990401 embryonic lung development ISS
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0048407 platelet-derived growth factor binding IPI


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000127947 PTPN12 / Q05209 / protein tyrosine phosphatase, non-receptor type 12  / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / complex / reaction
 ENSG00000137801 THBS1 / P07996 / thrombospondin 1  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000113296 THBS4 / P35443 / thrombospondin 4  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000169231 THBS3 / P49746 / thrombospondin 3  / complex / reaction
 ENSG00000186340 THBS2 / P35442 / thrombospondin 2  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction






 

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