ENSG00000141738


Homo sapiens

Features
Gene ID: ENSG00000141738
  
Biological name :GRB7
  
Synonyms : GRB7 / growth factor receptor bound protein 7 / Q14451
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 39737927
Gene end: 39747291
  
Corresponding Affymetrix probe sets: 210761_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463126
Ensembl peptide - ENSP00000403459
Ensembl peptide - ENSP00000463416
Ensembl peptide - ENSP00000310771
Ensembl peptide - ENSP00000377754
Ensembl peptide - ENSP00000377759
Ensembl peptide - ENSP00000377761
NCBI entrez gene - 2886     See in Manteia.
OMIM - 601522
RefSeq - XM_017024538
RefSeq - NM_001030002
RefSeq - NM_001242442
RefSeq - NM_001242443
RefSeq - NM_005310
RefSeq - XM_017024536
RefSeq - XM_017024537
RefSeq Peptide - NP_001317136
RefSeq Peptide - NP_005301
RefSeq Peptide - NP_001229371
RefSeq Peptide - NP_001025173
RefSeq Peptide - NP_001229372
swissprot - A0A0S2Z4F6
swissprot - J3QKK7
swissprot - J3QL76
swissprot - Q14451
Ensembl - ENSG00000141738
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-253b1.3ENSDARG00000042726Danio rerio
 GRB7ENSGALG00000036500Gallus gallus
 Grb7ENSMUSG00000019312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB10 / Q13322 / growth factor receptor bound protein 10ENSG0000010607051
GRB14 / Q14449 / growth factor receptor bound protein 14ENSG0000011529046
Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting proteinENSG0000007742023
RAPH1 / Q70E73 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1ENSG0000017316622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035032  Growth factor receptor-bound protein 7
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0017148 negative regulation of translation ISS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0034063 stress granule assembly ISS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0010494 cytoplasmic stress granule ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
GRB7 events in ERBB2 signaling
Signaling by SCF-KIT
Downstream signal transduction
Tie2 Signaling
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / complex / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / complex / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex / reaction
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction






 

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