Manteia

ENSG00000051382

Homo sapiens

Features

Gene ID:	ENSG00000051382

Biological name :	PIK3CB

Synonyms :	P42338 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / PIK3CB

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	3
Strand:	-1
Band:	q22.3
Gene start:	138652699
Gene end:	138834938

Corresponding Affymetrix probe sets:	212688_at (Human Genome U133 Plus 2.0 Array) 217620_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000419857 Ensembl peptide - ENSP00000419513 Ensembl peptide - ENSP00000420108 Ensembl peptide - ENSP00000438259 Ensembl peptide - ENSP00000420399 Ensembl peptide - ENSP00000289153 Ensembl peptide - ENSP00000417329 Ensembl peptide - ENSP00000417869 Ensembl peptide - ENSP00000418143 Ensembl peptide - ENSP00000418834 Ensembl peptide - ENSP00000419091 NCBI entrez gene - 5291 See in Manteia. OMIM - 602925 RefSeq - XM_017006621 RefSeq - NM_001256045 RefSeq - NM_006219 RefSeq - XM_005247530 RefSeq - XM_006713659 RefSeq - XM_011512895 RefSeq - XM_011512896 RefSeq - XM_017006619 RefSeq - XM_017006620 RefSeq Peptide - NP_006210 RefSeq Peptide - NP_001242974 swissprot - C9JYX0 swissprot - C9JNF6 swissprot - F8WDJ8 swissprot - H0Y871 swissprot - H7C527 swissprot - H7C565 swissprot - H7C5C3 swissprot - C9J345 swissprot - Q68DL0 swissprot - P42338 Ensembl - ENSG00000051382

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pik3cb	ENSDARG00000075253	Danio rerio
PIK3CB	ENSGALG00000005505	Gallus gallus
Pik3cb	ENSMUSG00000032462	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	ENSG00000171608	56
P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENSG00000121879	40
P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	ENSG00000105851	30
O00443 / PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	ENSG00000011405	26
O00750 / PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	ENSG00000133056	26
O75747 / PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	ENSG00000139144	21
PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3	ENSG00000078142	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420	Phosphatidylinositol 3-kinase, C2 domain
IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR008290	Phosphatidylinositol 3-kinase, Vps34 type
IPR011009	Protein kinase-like domain superfamily
IPR015433	Phosphatidylinositol kinase
IPR016024	Armadillo-type fold
IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
IPR029071	Ubiquitin-like domain superfamily
IPR035892	C2 domain superfamily
IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000187	activation of MAPK activity	TAS
biological_process	GO:0001935	endothelial cell proliferation	IEA
biological_process	GO:0001952	regulation of cell-matrix adhesion	IMP
biological_process	GO:0002250	adaptive immune response	IBA
biological_process	GO:0006661	phosphatidylinositol biosynthetic process	TAS
biological_process	GO:0006874	cellular calcium ion homeostasis	IEA
biological_process	GO:0006897	endocytosis	IEA
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0006935	chemotaxis	TAS
biological_process	GO:0006954	inflammatory response	IBA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IEA
biological_process	GO:0007165	signal transduction	NAS
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007411	axon guidance	TAS
biological_process	GO:0009611	response to wounding	IEA
biological_process	GO:0010508	positive regulation of autophagy	TAS
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0014065	phosphatidylinositol 3-kinase signaling	IMP
biological_process	GO:0016310	phosphorylation	IDA
biological_process	GO:0016477	cell migration	TAS
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0033031	positive regulation of neutrophil apoptotic process	IMP
biological_process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IEA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0040016	embryonic cleavage	IEA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0046854	phosphatidylinositol phosphorylation	IEA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0048015	phosphatidylinositol-mediated signaling	IEA
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0050900	leukocyte migration	TAS
biological_process	GO:0051897	positive regulation of protein kinase B signaling	TAS
biological_process	GO:0060055	angiogenesis involved in wound healing	IEA
biological_process	GO:0060326	cell chemotaxis	IBA
biological_process	GO:0070527	platelet aggregation	TAS
biological_process	GO:2000369	regulation of clathrin-dependent endocytosis	TAS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005730	nucleolus	IDA
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	IBA
cellular_component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA
cellular_component	GO:0030496	midbody	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IDA
molecular_function	GO:0016303	1-phosphatidylinositol-3-kinase activity	TAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0035004	phosphatidylinositol 3-kinase activity	TAS
molecular_function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA
molecular_function	GO:0043560	insulin receptor substrate binding	IEA
molecular_function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000113525	IL5 / P05113 / interleukin 5	/ complex / reaction
ENSG00000112715	VEGFA / P15692 / vascular endothelial growth factor A	/ complex / reaction
ENSG00000125650	PSPN / O60542 / persephin	/ complex
ENSG00000091181	IL5RA / Q01344 / interleukin 5 receptor subunit alpha	/ complex / reaction
ENSG00000128052	KDR / P35968 / kinase insert domain receptor	/ complex / reaction
ENSG00000100368	CSF2RB / P32927 / colony stimulating factor 2 receptor beta common subunit	/ complex / reaction
ENSG00000109458	GAB1 / Q13480 / GRB2 associated binding protein 1	/ complex / reaction
ENSG00000110395	CBL / P22681 / Cbl proto-oncogene	/ complex / reaction
ENSG00000168546	GFRA2 / O00451 / GDNF family receptor alpha 2	/ complex
ENSG00000164399	IL3 / P08700 / interleukin 3	/ complex / reaction
ENSG00000164400	CSF2 / P04141 / colony stimulating factor 2	/ complex / reaction
ENSG00000167601	AXL / P30530 / AXL receptor tyrosine kinase	/ complex / reaction
ENSG00000187266	EPOR / P19235 / erythropoietin receptor	/ complex / reaction
ENSG00000105647	O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2	/ complex
ENSG00000130427	EPO / P01588 / erythropoietin	/ complex / reaction
ENSG00000213809	KLRK1 / P26718 / killer cell lectin like receptor K1	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ reaction
ENSG00000134853	P16234 / PDGFRA / platelet derived growth factor receptor alpha	/ complex / reaction
ENSG00000113721	P09619 / PDGFRB / platelet derived growth factor receptor beta	/ complex / reaction
ENSG00000011600	O43914 / TYROBP / TYRO protein tyrosine kinase binding protein	/ complex / reaction
ENSG00000117461	PIK3R3 / Q92569 / phosphoinositide-3-kinase regulatory subunit 3	/ complex
ENSG00000163519	TRAT1 / Q6PIZ9 / T cell receptor associated transmembrane adaptor 1	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ reaction
ENSG00000169047	IRS1 / P35568 / insulin receptor substrate 1	/ complex / reaction
ENSG00000086730	LAT2 / Q9GZY6 / linker for activation of T cells family member 2	/ complex / reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000095970	TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2	/ complex / reaction
ENSG00000134539	KLRD1 / Q13241 / killer cell lectin like receptor D1	/ complex / reaction
ENSG00000185291	IL3RA / P26951 / interleukin 3 receptor subunit alpha	/ reaction / complex
ENSG00000033327	GAB2 / Q9UQC2 / GRB2 associated binding protein 2	/ complex / reaction
ENSG00000100311	PDGFB / P01127 / platelet derived growth factor subunit B	/ complex / reaction
ENSG00000198223	CSF2RA / P15509 / colony stimulating factor 2 receptor alpha subunit	/ reaction / complex
ENSG00000197461	PDGFA / P04085 / platelet derived growth factor subunit A	/ complex / reaction
ENSG00000166710	B2M / P61769 / beta-2-microglobulin	/ complex / reaction
ENSG00000179295	PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	/ complex
ENSG00000198400	NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction
ENSG00000134259	NGF / P01138 / nerve growth factor	/ complex / reaction
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ complex / reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000205809	KLRC2 / P26717 / killer cell lectin like receptor C2	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000166225	FRS2 / Q8WU20 / fibroblast growth factor receptor substrate 2	/ complex
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000171119	NRTN / Q99748 / neurturin	/ complex
ENSG00000146013	GFRA3 / O60609 / GDNF family receptor alpha 3	/ complex
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ complex / reaction
ENSG00000143226	FCGR2A / P12318 / Fc fragment of IgG receptor IIa	/ complex / reaction
ENSG00000125861	GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4	/ complex
ENSG00000154188	ANGPT1 / Q15389 / angiopoietin 1	/ complex / reaction
ENSG00000165731	RET / P07949 / ret proto-oncogene	/ complex
ENSG00000168621	GDNF / P39905 / glial cell derived neurotrophic factor	/ complex
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ complex / reaction
ENSG00000164924	YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	/ complex / reaction
ENSG00000161270	NPHS1 / O60500 / NPHS1, nephrin	/ complex / reaction
ENSG00000151892	GFRA1 / P56159 / GDNF family receptor alpha 1	/ complex
ENSG00000183853	Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ complex / reaction
ENSG00000198087	CD2AP / Q9Y5K6 / CD2 associated protein	/ complex / reaction
ENSG00000171608	O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	/ reaction
ENSG00000203747	FCGR3A / P08637 / Fc fragment of IgG receptor IIIa	/ complex / reaction
ENSG00000150337	FCGR1A / P12314 / Fc fragment of IgG receptor Ia	/ complex / reaction
ENSG00000027869	Q9NP31 / SH2D2A / SH2 domain containing 2A	/ complex / reaction
ENSG00000117407	ARTN / Q5T4W7 / artemin	/ complex
ENSG00000211893	IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)	/ complex / reaction
ENSG00000120156	TEK / Q02763 / TEK receptor tyrosine kinase	/ complex / reaction
ENSG00000211896	IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)	/ complex / reaction
ENSG00000211892	IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr