Manteia

ENSG00000254087

Homo sapiens

Features

Gene ID:	ENSG00000254087

Biological name :	LYN

Synonyms :	LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	8
Strand:	1
Band:	q12.1
Gene start:	55879813
Gene end:	56014168

Corresponding Affymetrix probe sets:	202625_at (Human Genome U133 Plus 2.0 Array) 202626_s_at (Human Genome U133 Plus 2.0 Array) 210754_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000428924 Ensembl peptide - ENSP00000428313 Ensembl peptide - ENSP00000428424 NCBI entrez gene - 4067 See in Manteia. OMIM - 165120 RefSeq - XM_017013416 RefSeq - NM_001111097 RefSeq - NM_002350 RefSeq - XM_011517529 RefSeq Peptide - NP_002341 RefSeq Peptide - NP_001104567 swissprot - P07948 swissprot - E5RJ37 Ensembl - ENSG00000254087

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lyn	ENSDARG00000067916	Danio rerio
LYN	ENSGALG00000042321	Gallus gallus
Lyn	ENSMUSG00000042228	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinase	ENSG00000101336	70
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	ENSG00000182866	63
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinase	ENSG00000136573	60
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	ENSG00000010810	57
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase	ENSG00000176105	57
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinase	ENSG00000000938	55
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	ENSG00000197122	54
FRK / P42685 / fyn related Src family tyrosine kinase	ENSG00000111816	47
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	ENSG00000125508	35
PTK6 / Q13882 / protein tyrosine kinase 6	ENSG00000101213	34

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001452	SH3 domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR035748	Tyrosine-protein kinase Lyn, SH3 domain
IPR035852	Tyrosine-protein kinase Lyn, SH2 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001782	B cell homeostasis	ISS
biological_process	GO:0001817	regulation of cytokine production	ISS
biological_process	GO:0001932	regulation of protein phosphorylation	TAS
biological_process	GO:0001933	negative regulation of protein phosphorylation	ISS
biological_process	GO:0001934	positive regulation of protein phosphorylation	IGI
biological_process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002431	Fc receptor mediated stimulatory signaling pathway	IBA
biological_process	GO:0002513	tolerance induction to self antigen	TAS
biological_process	GO:0002553	histamine secretion by mast cell	IEA
biological_process	GO:0002576	platelet degranulation	IBA
biological_process	GO:0002762	negative regulation of myeloid leukocyte differentiation	IEA
biological_process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	TAS
biological_process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	ISS
biological_process	GO:0002902	regulation of B cell apoptotic process	IBA
biological_process	GO:0006468	protein phosphorylation	IDA
biological_process	GO:0006954	inflammatory response	IBA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IDA
biological_process	GO:0006991	response to sterol depletion	IEA
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IMP
biological_process	GO:0007417	central nervous system development	IBA
biological_process	GO:0007596	blood coagulation	TAS
biological_process	GO:0008284	positive regulation of cell proliferation	ISS
biological_process	GO:0008285	negative regulation of cell proliferation	IMP
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0009725	response to hormone	ISS
biological_process	GO:0009743	response to carbohydrate	IEA
biological_process	GO:0010976	positive regulation of neuron projection development	IMP
biological_process	GO:0014003	oligodendrocyte development	IEA
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
biological_process	GO:0030097	hemopoiesis	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030218	erythrocyte differentiation	ISS
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0030889	negative regulation of B cell proliferation	IBA
biological_process	GO:0031175	neuron projection development	IEA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0031663	lipopolysaccharide-mediated signaling pathway	ISS
biological_process	GO:0031668	cellular response to extracellular stimulus	IEA
biological_process	GO:0032868	response to insulin	IEA
biological_process	GO:0033003	regulation of mast cell activation	ISS
biological_process	GO:0033628	regulation of cell adhesion mediated by integrin	IMP
biological_process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	ISS
biological_process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	ISS
biological_process	GO:0034605	cellular response to heat	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042327	positive regulation of phosphorylation	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISS
biological_process	GO:0043200	response to amino acid	IEA
biological_process	GO:0043304	regulation of mast cell degranulation	IBA
biological_process	GO:0043407	negative regulation of MAP kinase activity	ISS
biological_process	GO:0043434	response to peptide hormone	IEA
biological_process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IEA
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045646	regulation of erythrocyte differentiation	ISS
biological_process	GO:0046777	protein autophosphorylation	IDA
biological_process	GO:0048013	ephrin receptor signaling pathway	TAS
biological_process	GO:0048678	response to axon injury	IEA
biological_process	GO:0050663	cytokine secretion	IEA
biological_process	GO:0050707	regulation of cytokine secretion	IEA
biological_process	GO:0050727	regulation of inflammatory response	IEA
biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0050777	negative regulation of immune response	TAS
biological_process	GO:0050853	B cell receptor signaling pathway	IEA
biological_process	GO:0050855	regulation of B cell receptor signaling pathway	IBA
biological_process	GO:0050861	positive regulation of B cell receptor signaling pathway	IEA
biological_process	GO:0050900	leukocyte migration	TAS
biological_process	GO:0051272	positive regulation of cellular component movement	IDA
biological_process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IEA
biological_process	GO:0060252	positive regulation of glial cell proliferation	IEA
biological_process	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	IEA
biological_process	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	TAS
biological_process	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	IDA
biological_process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISS
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISS
biological_process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	IEA
biological_process	GO:0070667	negative regulation of mast cell proliferation	IBA
biological_process	GO:0070668	positive regulation of mast cell proliferation	IMP
biological_process	GO:0071300	cellular response to retinoic acid	IMP
biological_process	GO:0090025	regulation of monocyte chemotaxis	IMP
biological_process	GO:0090330	regulation of platelet aggregation	IBA
biological_process	GO:0097028	dendritic cell differentiation	IBA
biological_process	GO:1902532	negative regulation of intracellular signal transduction	ISS
biological_process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP
biological_process	GO:2000670	positive regulation of dendritic cell apoptotic process	IBA
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005758	mitochondrial intermembrane space	IEA
cellular_component	GO:0005794	Golgi apparatus	IDA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005913	cell-cell adherens junction	IEA
cellular_component	GO:0014069	postsynaptic density	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030061	mitochondrial crista	IEA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
cellular_component	GO:0031966	mitochondrial membrane	IEA
cellular_component	GO:0034666	integrin alpha2-beta1 complex	IEA
cellular_component	GO:0042629	mast cell granule	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IDA
cellular_component	GO:0045121	membrane raft	IDA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA
molecular_function	GO:0004716	obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity	TAS
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005161	platelet-derived growth factor receptor binding	IEA
molecular_function	GO:0005178	integrin binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	NAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0017124	SH3 domain binding	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0043015	gamma-tubulin binding	IEA
molecular_function	GO:0043208	glycosphingolipid binding	IEA
molecular_function	GO:0044325	ion channel binding	IPI
molecular_function	GO:0046875	ephrin receptor binding	IPI
molecular_function	GO:0051219	phosphoprotein binding	IEA
molecular_function	GO:0140031	phosphorylation-dependent protein binding	IPI

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000187266	EPOR / P19235 / erythropoietin receptor	/ complex
ENSG00000130427	EPO / P01588 / erythropoietin	/ complex / reaction
ENSG00000112964	GHR / P10912 / growth hormone receptor	/ complex / reaction
ENSG00000109458	GAB1 / Q13480 / GRB2 associated binding protein 1	/ complex / reaction
ENSG00000121879	P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	/ complex / reaction
ENSG00000141506	PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5	/ complex / reaction
ENSG00000158869	FCER1G / P30273 / Fc fragment of IgE receptor Ig	/ complex / reaction
ENSG00000088053	GP6 / Q9HCN6 / glycoprotein VI platelet	/ complex / reaction
ENSG00000156299	TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1	/ complex / reaction
ENSG00000051382	P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000259384	GH1 / P01241 / growth hormone 1	/ complex / reaction
ENSG00000136487	GH2 / P01242 / growth hormone 2	/ complex / reaction
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000099942	CRKL / P46109 / CRK like proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000105851	P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	/ complex / reaction
ENSG00000176884	GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1	/ complex / reaction
ENSG00000171608	O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction
ENSG00000107263	Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ complex
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000007312	CD79B / P40259 / CD79b molecule	/ reaction
ENSG00000012124	CD22 / P20273 / CD22 molecule	/ reaction
ENSG00000090776	EFNB1 / P98172 / ephrin B1	/ complex / reaction
ENSG00000105369	CD79A / P11912 / CD79a molecule	/ reaction
ENSG00000108947	EFNB3 / Q15768 / ephrin B3	/ complex / reaction
ENSG00000125266	EFNB2 / P52799 / ephrin B2	/ complex / reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000065675	PRKCQ / Q04759 / protein kinase C theta	/ reaction
ENSG00000066248	NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor	/ complex / reaction
ENSG00000166523	CLEC4E / Q9ULY5 / C-type lectin domain family 4 member E	/ reaction
ENSG00000173757	P51692 / STAT5B / signal transducer and activator of transcription 5B	/ complex / reaction
ENSG00000149534	MS4A2 / Q01362 / membrane spanning 4-domains A2	/ complex / reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000086730	LAT2 / Q9GZY6 / linker for activation of T cells family member 2	/ reaction
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000033327	GAB2 / Q9UQC2 / GRB2 associated binding protein 2	/ reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ reaction
ENSG00000197943	PLCG2 / P16885 / phospholipase C gamma 2	/ complex / reaction
ENSG00000126561	P42229 / STAT5A / signal transducer and activator of transcription 5A	/ complex / reaction
ENSG00000179639	FCER1A / P12319 / Fc fragment of IgE receptor Ia	/ complex / reaction
ENSG00000211891	IGHE / P01854 / immunoglobulin heavy constant epsilon	/ complex / reaction
ENSG00000211898	IGHD / P01880 / immunoglobulin heavy constant delta	/ reaction
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ complex / reaction
ENSG00000211899	IGHM / P01871 / immunoglobulin heavy constant mu	/ reaction
ENSG00000205846	CLEC6A / Q6EIG7 / C-type lectin domain containing 6A	/ reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ complex
ENSG00000273079	GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr