Manteia

ENSG00000141968

Homo sapiens

Features

Gene ID:	ENSG00000141968

Biological name :	VAV1

Synonyms :	P15498 / VAV1 / vav guanine nucleotide exchange factor 1

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	19
Strand:	1
Band:	p13.3
Gene start:	6772714
Gene end:	6857366

Corresponding Affymetrix probe sets:	206219_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000302269 Ensembl peptide - ENSP00000469450 Ensembl peptide - ENSP00000472803 Ensembl peptide - ENSP00000472929 Ensembl peptide - ENSP00000443242 NCBI entrez gene - 7409 See in Manteia. OMIM - 164875 RefSeq - XM_005259642 RefSeq - NM_001258206 RefSeq - NM_001258207 RefSeq - NM_005428 RefSeq Peptide - NP_005419 RefSeq Peptide - NP_001245135 RefSeq Peptide - NP_001245136 swissprot - A0A0A0MR07 swissprot - F5H5P4 swissprot - P15498 swissprot - Q96D37 Ensembl - ENSG00000141968

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
Vav1	ENSMUSG00000034116	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	ENSG00000134215	59
VAV2 / P52735 / vav guanine nucleotide exchange factor 2	ENSG00000160293	52
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	ENSG00000124126	18
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2	ENSG00000046889	17
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2	ENSG00000146426	16
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1	ENSG00000156299	15
Q96N96 / SPATA13 / spermatogenesis associated 13	ENSG00000182957	15
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4	ENSG00000136002	14
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7	ENSG00000102606	13
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6	ENSG00000129675	13
AL359736.1	ENSG00000273167	13
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9	ENSG00000131089	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR000219	Dbl homology (DH) domain
IPR000980	SH2 domain
IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001452	SH3 domain
IPR001715	Calponin homology domain
IPR001849	Pleckstrin homology domain
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003096	Smooth muscle protein/calponin
IPR011993	PH-like domain superfamily
IPR022613	Calmodulin-regulated spectrin-associated protein, CH domain
IPR028530	Protein vav1
IPR035729	VAV1 protein, second SH3 domain
IPR035730	VAV1 protein, first SH3 domain
IPR035879	VAV1, SH2 domain
IPR035899	Dbl homology (DH) domain superfamily
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily
IPR036872	CH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006909	phagocytosis	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007229	integrin-mediated signaling pathway	IEA
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0008361	regulation of cell size	IGI
biological_process	GO:0019221	cytokine-mediated signaling pathway	TAS
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0030217	T cell differentiation	IEA
biological_process	GO:0030593	neutrophil chemotaxis	IEA
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0035023	regulation of Rho protein signal transduction	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
biological_process	GO:0042110	T cell activation	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	TAS
biological_process	GO:0043087	regulation of GTPase activity	IGI
biological_process	GO:0043547	positive regulation of GTPase activity	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IEA
biological_process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IEA
biological_process	GO:0046854	phosphatidylinositol phosphorylation	IEA
biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	TAS
biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	TAS
biological_process	GO:0051897	positive regulation of protein kinase B signaling	TAS
biological_process	GO:0065009	regulation of molecular function	IEA
biological_process	GO:0072593	reactive oxygen species metabolic process	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005911	cell-cell junction	IEA
molecular_function	GO:0001784	phosphotyrosine residue binding	IPI
molecular_function	GO:0003700	DNA-binding transcription factor activity	TAS
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0030676	Rac guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS

Pathways (from Reactome)

Pathway description

GPVI-mediated activation cascade

PIP3 activates AKT signaling

Signaling by SCF-KIT

NRAGE signals death through JNK

Rho GTPase cycle

Regulation of actin dynamics for phagocytic cup formation

Constitutive Signaling by Aberrant PI3K in Cancer

FCERI mediated MAPK activation

FCERI mediated Ca+2 mobilization

CD28 dependent Vav1 pathway

G alpha (12/13) signalling events

VEGFA-VEGFR2 Pathway

Interleukin-3, Interleukin-5 and GM-CSF signaling

VEGFR2 mediated vascular permeability

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Regulation of signaling by CBL

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ complex / reaction
ENSG00000010810	FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	/ reaction / complex
ENSG00000187266	EPOR / P19235 / erythropoietin receptor	/ complex / reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ complex / reaction
ENSG00000130427	EPO / P01588 / erythropoietin	/ complex / reaction
ENSG00000077264	PAK3 / O75914 / p21 (RAC1) activated kinase 3	/ complex / reaction
ENSG00000110395	CBL / P22681 / Cbl proto-oncogene	/ complex / reaction
ENSG00000128340	RAC2 / P15153 / Rac family small GTPase 2	/ reaction
ENSG00000121594	CD80 / P33681 / CD80 molecule	/ complex / reaction
ENSG00000114013	CD86 / P42081 / CD86 molecule	/ complex / reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ reaction
ENSG00000141968	VAV1 / P15498 / vav guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000149269	PAK1 / Q13153 / p21 (RAC1) activated kinase 1	/ complex / reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction
ENSG00000010671	BTK / Q06187 / Bruton tyrosine kinase	/ reaction / complex
ENSG00000177885	GRB2 / P62993 / growth factor receptor bound protein 2	/ complex / reaction
ENSG00000178562	CD28 / P10747 / CD28 molecule	/ complex / reaction
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000070831	CDC42 / P60953 / cell division cycle 42	/ reaction
ENSG00000177455	CD19 / P15391 / CD19 molecule	/ complex
ENSG00000180370	PAK2 / Q13177 / p21 (RAC1) activated kinase 2	/ complex / reaction
ENSG00000134215	VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3	/ complex / reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000177105	RHOG / P84095 / ras homolog family member G	/ reaction
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction
ENSG00000165025	SYK / P43405 / spleen associated tyrosine kinase	/ complex / reaction
ENSG00000135605	TEC / P42680 / tec protein tyrosine kinase	/ reaction / complex
ENSG00000113263	ITK / Q08881 / IL2 inducible T cell kinase	/ reaction / complex
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ complex / reaction
ENSG00000143226	FCGR2A / P12318 / Fc fragment of IgG receptor IIa	/ complex / reaction
ENSG00000145675	P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1	/ complex / reaction
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ complex / reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ complex / reaction
ENSG00000099942	CRKL / P46109 / CRK like proto-oncogene, adaptor protein	/ complex / reaction
ENSG00000213658	LAT / O43561 / linker for activation of T cells	/ complex / reaction
ENSG00000197943	PLCG2 / P16885 / phospholipase C gamma 2	/ complex / reaction
ENSG00000197122	SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	/ reaction
ENSG00000171608	O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	/ complex / reaction
ENSG00000160691	SHC1 / P29353 / SHC adaptor protein 1	/ complex / reaction
ENSG00000107263	Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000203747	FCGR3A / P08637 / Fc fragment of IgG receptor IIIa	/ complex / reaction
ENSG00000150337	FCGR1A / P12314 / Fc fragment of IgG receptor Ia	/ complex / reaction
ENSG00000160293	VAV2 / P52735 / vav guanine nucleotide exchange factor 2	/ complex / reaction
ENSG00000185950	IRS2 / Q9Y4H2 / insulin receptor substrate 2	/ complex / reaction
ENSG00000211893	IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)	/ complex / reaction
ENSG00000211896	IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)	/ complex / reaction
ENSG00000211892	IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)	/ complex / reaction
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000115904	SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1	/ complex / reaction
ENSG00000254087	LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr