ENSG00000182866


Homo sapiens

Features
Gene ID: ENSG00000182866
  
Biological name :LCK
  
Synonyms : LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.2
Gene start: 32251239
Gene end: 32286165
  
Corresponding Affymetrix probe sets: 204890_s_at (Human Genome U133 Plus 2.0 Array)   204891_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337825
Ensembl peptide - ENSP00000362658
Ensembl peptide - ENSP00000477713
Ensembl peptide - ENSP00000436554
Ensembl peptide - ENSP00000435605
Ensembl peptide - ENSP00000434525
Ensembl peptide - ENSP00000431517
Ensembl peptide - ENSP00000362665
Ensembl peptide - ENSP00000362663
Ensembl peptide - ENSP00000328213
NCBI entrez gene - 3932     See in Manteia.
OMIM - 153390
RefSeq - XM_011541455
RefSeq - NM_001042771
RefSeq - NM_005356
RefSeq - XM_011541453
RefSeq - XM_011541454
RefSeq Peptide - NP_005347
RefSeq Peptide - NP_001036236
swissprot - F8W6B9
swissprot - Q573B4
swissprot - E9PQ10
swissprot - P06239
swissprot - E9PKQ8
swissprot - E9PJ92
swissprot - E9PI33
swissprot - A0A0S2Z3Y8
swissprot - E9PAP0
swissprot - A0A0S2Z3T3
Ensembl - ENSG00000182866
  
Related genetic diseases (OMIM): 615758 - ?Immunodeficiency 22, 615758
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lckENSDARG00000102525Danio rerio
 LCKENSGALG00000000466Gallus gallus
 LckENSMUSG00000000409Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133666
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408764
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657361
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081057
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610557
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093854
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712254
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181646
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550839
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035749  Lck, SH3 domain
 IPR035850  Tyrosine-protein kinase Lck, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006882 cellular zinc ion homeostasis ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis NAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030217 T cell differentiation ISS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050853 B cell receptor signaling pathway IBA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway NAS
 biological_processGO:0050870 positive regulation of T cell activation ISS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051249 regulation of lymphocyte activation NAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0000242 pericentriolar material ISS
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042169 SH2 domain binding ISS
 molecular_functionGO:0042608 T cell receptor binding IPI
 molecular_functionGO:0042609 CD4 receptor binding IPI
 molecular_functionGO:0042610 CD8 receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001508 Failure to thrive 
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 HP:0002014 Diarrhea 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0002721 Immunodeficiency 
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 HP:0002960 Autoimmune disease 
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 HP:0003593 Early onset 
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 HP:0012490 Panniculitis "Inflammation of `adipose tissue` (FMA)20110)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction
 ENSG00000213809 KLRK1 / P26718 / killer cell lectin like receptor K1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / complex / reaction
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / complex / reaction
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000121594 CD80 / P33681 / CD80 molecule  / complex / reaction
 ENSG00000114013 CD86 / P42081 / CD86 molecule  / complex / reaction
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000188389 PDCD1 / Q15116 / programmed cell death 1  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / complex / reaction
 ENSG00000120217 CD274 / Q9NZQ7 / CD274 molecule  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction
 ENSG00000197646 Q9BQ51 / PDCD1LG2 / programmed cell death 1 ligand 2  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000095970 TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2  / complex / reaction
 ENSG00000134539 KLRD1 / Q13241 / killer cell lectin like receptor D1  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000134242 PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22  / reaction
 ENSG00000205809 KLRC2 / P26717 / killer cell lectin like receptor C2  / complex / reaction
 ENSG00000149177 PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J  / reaction






 

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