Manteia

ENSG00000101213

Homo sapiens

Features

Gene ID:	ENSG00000101213

Biological name :	PTK6

Synonyms :	protein tyrosine kinase 6 / PTK6 / Q13882

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	20
Strand:	-1
Band:	q13.33
Gene start:	63528001
Gene end:	63537370

Corresponding Affymetrix probe sets:	1553114_a_at (Human Genome U133 Plus 2.0 Array) 206482_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000217185 Ensembl peptide - ENSP00000442460 NCBI entrez gene - 5753 See in Manteia. OMIM - 602004 RefSeq - XM_017027982 RefSeq - NM_001256358 RefSeq - NM_005975 RefSeq Peptide - NP_005966 RefSeq Peptide - NP_001243287 swissprot - Q13882 Ensembl - ENSG00000101213

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ptk6a	ENSDARG00000017947	Danio rerio
ptk6b	ENSDARG00000059956	Danio rerio
Ptk6	ENSMUSG00000038751	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	ENSG00000125508	45
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase	ENSG00000010810	44
FRK / P42685 / fyn related Src family tyrosine kinase	ENSG00000111816	44
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase	ENSG00000176105	44
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase	ENSG00000197122	44
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinase	ENSG00000000938	43
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinase	ENSG00000101336	41
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinase	ENSG00000136573	41
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	ENSG00000182866	40
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase	ENSG00000254087	38

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR000980	SH2 domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001452	SH3 domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain
IPR035846	PTK6, SH2 domain
IPR036028	SH3-like domain superfamily
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006468	protein phosphorylation	TAS
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA
biological_process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA
biological_process	GO:0009968	negative regulation of signal transduction	TAS
biological_process	GO:0010976	positive regulation of neuron projection development	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0016477	cell migration	IDA
biological_process	GO:0038083	peptidyl-tyrosine autophosphorylation	IBA
biological_process	GO:0038128	ERBB2 signaling pathway	TAS
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	TAS
biological_process	GO:0045087	innate immune response	IBA
biological_process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	TAS
biological_process	GO:0045787	positive regulation of cell cycle	TAS
biological_process	GO:0045926	negative regulation of growth	IEA
biological_process	GO:0046777	protein autophosphorylation	IMP
biological_process	GO:0060575	intestinal epithelial cell differentiation	IEA
biological_process	GO:0061099	negative regulation of protein tyrosine kinase activity	IDA
biological_process	GO:0071300	cellular response to retinoic acid	IMP
cellular_component	GO:0001726	ruffle	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016604	nuclear body	IDA
cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004713	protein tyrosine kinase activity	TAS
molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS
molecular_function	GO:0005102	signaling receptor binding	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0042802	identical protein binding	IPI

Pathways (from Reactome)

Pathway description

SCF(Skp2)-mediated degradation of p27/p21

Cyclin D associated events in G1

ERBB2 Activates PTK6 Signaling

PTK6 Regulates Proteins Involved in RNA Processing

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

PTK6 Regulates Cell Cycle

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Down-Regulation

PTK6 Expression

PTK6 Activates STAT3

PTK6 promotes HIF1A stabilization

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000050820	BCAR1 / P56945 / BCAR1, Cas family scaffolding protein	/ complex / reaction
ENSG00000110092	CCND1 / P24385 / cyclin D1	/ complex / reaction
ENSG00000111276	CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B	/ complex / reaction
ENSG00000089159	PXN / P49023 / paxillin	/ complex / reaction
ENSG00000168610	STAT3 / P40763 / signal transducer and activator of transcription 3	/ complex / reaction
ENSG00000110395	CBL / P22681 / Cbl proto-oncogene	/ reaction
ENSG00000121774	Q07666 / KHDRBS1 / KH RNA binding domain containing, signal transduction associated 1	/ complex / reaction
ENSG00000188906	LRRK2 / Q5S007 / leucine rich repeat kinase 2	/ complex / reaction
ENSG00000112232	Q5VWX1 / KHDRBS2 / KH RNA binding domain containing, signal transduction associated 2	/ reaction
ENSG00000100644	HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit	/ reaction
ENSG00000184557	SOCS3 / O14543 / suppressor of cytokine signaling 3	/ complex / reaction
ENSG00000142208	AKT1 / P31749 / AKT serine/threonine kinase 1	/ complex / reaction
ENSG00000131773	O75525 / KHDRBS3 / KH RNA binding domain containing, signal transduction associated 3	/ reaction
ENSG00000116560	SFPQ / P23246 / splicing factor proline and glutamine rich	/ reaction
ENSG00000196396	PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1	/ complex / reaction
ENSG00000178078	STAP2 / Q9UGK3 / signal transducing adaptor family member 2	/ complex / reaction
ENSG00000125508	SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	/ reaction
ENSG00000115325	DOK1 / Q99704 / docking protein 1	/ complex / reaction
ENSG00000113070	HBEGF / Q99075 / heparin binding EGF like growth factor	/ complex / reaction
ENSG00000124882	EREG / O14944 / epiregulin	/ complex / reaction
ENSG00000178568	ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4	/ complex / reaction
ENSG00000135446	CDK4 / P11802 / cyclin dependent kinase 4	/ complex / reaction
ENSG00000136235	GPNMB / Q14956 / glycoprotein nmb	/ complex / reaction
ENSG00000138798	EGF / P01133 / epidermal growth factor	/ complex / reaction
ENSG00000158458	NRG2 / O14511 / neuregulin 2	/ complex / reaction
ENSG00000146648	EGFR / P00533 / epidermal growth factor receptor	/ complex / reaction
ENSG00000157168	NRG1 / Q02297 / neuregulin 1	/ complex / reaction
ENSG00000065361	ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3	/ complex / reaction
ENSG00000141736	ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2	/ complex / reaction
ENSG00000186635	ARAP1 / Q96P48 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	/ complex / reaction
ENSG00000174808	BTC / P35070 / betacellulin	/ complex / reaction
ENSG00000169752	NRG4 / Q8WWG1 / neuregulin 4	/ complex / reaction
ENSG00000160007	Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr