ENSG00000135446


Homo sapiens

Features
Gene ID: ENSG00000135446
  
Biological name :CDK4
  
Synonyms : CDK4 / cyclin dependent kinase 4 / P11802
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q14.1
Gene start: 57747727
Gene end: 57756013
  
Corresponding Affymetrix probe sets: 202246_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449179
Ensembl peptide - ENSP00000449725
Ensembl peptide - ENSP00000449391
Ensembl peptide - ENSP00000257904
Ensembl peptide - ENSP00000316889
Ensembl peptide - ENSP00000446763
Ensembl peptide - ENSP00000447005
Ensembl peptide - ENSP00000447274
Ensembl peptide - ENSP00000447779
Ensembl peptide - ENSP00000448098
Ensembl peptide - ENSP00000448885
Ensembl peptide - ENSP00000448963
NCBI entrez gene - 1019     See in Manteia.
OMIM - 123829
RefSeq - NM_000075
RefSeq Peptide - NP_000066
swissprot - F8VXD2
swissprot - F8VYH9
swissprot - F8VYY1
swissprot - F8VZ13
swissprot - F8VZ51
swissprot - F8VZZ0
swissprot - F8W1L8
swissprot - P11802
swissprot - A0A024RBB6
swissprot - Q96BE9
swissprot - F8VTV8
swissprot - F8VWX7
Ensembl - ENSG00000135446
  
Related genetic diseases (OMIM): 609048 - {Melanoma, cutaneous malignant, 3}, 609048
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk4ENSDARG00000087937Danio rerio
 Cdk4ENSMUSG00000006728Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK6 / Q00534 / cyclin dependent kinase 6ENSG0000010581070
CDK2 / P24941 / cyclin dependent kinase 2ENSG0000012337444
CDK3 / Q00526 / cyclin dependent kinase 3ENSG0000025050644
CDK5 / Q00535 / cyclin dependent kinase 5ENSG0000016488543
CDK1 / P06493 / cyclin dependent kinase 1ENSG0000017031242
CDK10 / Q15131 / cyclin dependent kinase 10ENSG0000018532441
CDK11A / Q9UQ88 / cyclin dependent kinase 11AENSG0000000812839
CDK11B / cyclin dependent kinase 11BENSG0000024833339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045787 positive regulation of cell cycle TAS
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046890 regulation of lipid biosynthetic process IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0050994 regulation of lipid catabolic process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IEA
 biological_processGO:1904637 cellular response to ionomycin IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097129 cyclin D2-CDK4 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding IPI


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000488 Retinopathy 
Show

 HP:0000958 Dry skin 
Show

 HP:0001480 Freckling 
Show

 HP:0001482 Subcutaneous nodules 
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 HP:0001595 Hair abnormality 
Show

 HP:0002071 Extrapyramidal signs 
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 HP:0002579 Gastrointestinal dysmotility 
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 HP:0002861 Malignant melanoma "A malignant skin tumor of originating from melanocytes, pigment cells normally present in the epidermis and sometimes in the dermis." [HPO:curators]
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 HP:0002894 Pancreatic cancer 
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 HP:0003764 Abnormal or excess nevi 
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 HP:0006753 Increased gastric cancer 
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 HP:0012211 Abnormal renal physiology "Any functional anomaly of the `kidney` (FMA:7203)." [HPO:probinson]
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 HP:0100013 Neoplasia of the breast 
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 HP:0100763 Abnormality of the lymphatic system 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / complex
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / complex / reaction
 ENSG00000116455 WDR77 / Q9BQA1 / WD repeat domain 77  / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000134480 CCNH / P51946 / cyclin H  / reaction
 ENSG00000123080 CDKN2C / P42773 / cyclin dependent kinase inhibitor 2C  / complex / reaction
 ENSG00000020426 MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor  / reaction
 ENSG00000134058 CDK7 / P50613 / cyclin dependent kinase 7  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / reaction
 ENSG00000133740 E2F5 / Q15329 / E2F transcription factor 5  / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / reaction
 ENSG00000080839 RBL1 / P28749 / RB transcriptional corepressor like 1  / reaction
 ENSG00000205250 E2F4 / Q16254 / E2F transcription factor 4  / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / reaction
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / reaction
 ENSG00000147889 CDKN2A / P42771 / Q8N726 / cyclin dependent kinase inhibitor 2A  / complex / reaction
 ENSG00000172301 COPRS / Q9NQ92 / coordinator of PRMT5 and differentiation stimulator  / complex / reaction
 ENSG00000147883 CDKN2B / P42772 / cyclin dependent kinase inhibitor 2B  / complex / reaction
 ENSG00000129355 CDKN2D / P55273 / cyclin dependent kinase inhibitor 2D  / complex / reaction






 

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