Manteia

ENSG00000123374

Homo sapiens

Features

Gene ID:	ENSG00000123374

Biological name :	CDK2

Synonyms :	CDK2 / cyclin dependent kinase 2 / P24941

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	12
Strand:	1
Band:	q13.2
Gene start:	55966769
Gene end:	55972784

Corresponding Affymetrix probe sets:	204252_at (Human Genome U133 Plus 2.0 Array) 211803_at (Human Genome U133 Plus 2.0 Array) 211804_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000266970 Ensembl peptide - ENSP00000452514 Ensembl peptide - ENSP00000452138 Ensembl peptide - ENSP00000450983 Ensembl peptide - ENSP00000393605 Ensembl peptide - ENSP00000243067 NCBI entrez gene - 1017 See in Manteia. OMIM - 116953 RefSeq - XM_011537732 RefSeq - NM_001290230 RefSeq - NM_001798 RefSeq - NM_052827 RefSeq Peptide - NP_439892 RefSeq Peptide - NP_001277159 RefSeq Peptide - NP_001789 swissprot - A0A024RB10 swissprot - A0A024RB77 swissprot - G3V5T9 swissprot - G3V317 swissprot - P24941 swissprot - E7ESI2 Ensembl - ENSG00000123374

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cdk2	ENSDARG00000026577	Danio rerio
CDK2	ENSGALG00000032699	Gallus gallus
Cdk2	ENSMUSG00000025358	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CDK3 / Q00526 / cyclin dependent kinase 3	ENSG00000250506	75
CDK1 / P06493 / cyclin dependent kinase 1	ENSG00000170312	65
CDK5 / Q00535 / cyclin dependent kinase 5	ENSG00000164885	58
CDK6 / Q00534 / cyclin dependent kinase 6	ENSG00000105810	48
CDK4 / P11802 / cyclin dependent kinase 4	ENSG00000135446	45
CDK11B / cyclin dependent kinase 11B	ENSG00000248333	45
CDK11A / Q9UQ88 / cyclin dependent kinase 11A	ENSG00000008128	44
CDK10 / Q15131 / cyclin dependent kinase 10	ENSG00000185324	44

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	TAS
biological_process	GO:0000086	G2/M transition of mitotic cell cycle	NAS
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006260	DNA replication	TAS
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006468	protein phosphorylation	IDA
biological_process	GO:0006813	potassium ion transport	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007099	centriole replication	IMP
biological_process	GO:0007265	Ras protein signal transduction	IEP
biological_process	GO:0007275	multicellular organism development	IBA
biological_process	GO:0008284	positive regulation of cell proliferation	IDA
biological_process	GO:0010033	response to organic substance	IBA
biological_process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IBA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0016572	histone phosphorylation	IDA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IDA
biological_process	GO:0031571	mitotic G1 DNA damage checkpoint	TAS
biological_process	GO:0032298	positive regulation of DNA-dependent DNA replication initiation	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0051298	centrosome duplication	TAS
biological_process	GO:0051301	cell division	IEA
biological_process	GO:0051321	meiotic cell cycle	TAS
biological_process	GO:0051436	obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS
biological_process	GO:0051439	obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS
biological_process	GO:0051726	regulation of cell cycle	IEA
biological_process	GO:0060968	regulation of gene silencing	IDA
biological_process	GO:0071732	cellular response to nitric oxide	TAS
biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	TAS
cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA
cellular_component	GO:0000781	chromosome, telomeric region	IEA
cellular_component	GO:0000793	condensed chromosome	IEA
cellular_component	GO:0000805	X chromosome	IEA
cellular_component	GO:0000806	Y chromosome	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005667	transcription factor complex	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005813	centrosome	TAS
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0015030	Cajal body	IEA
cellular_component	GO:0097123	cyclin A1-CDK2 complex	IEA
cellular_component	GO:0097124	cyclin A2-CDK2 complex	IDA
cellular_component	GO:0097134	cyclin E1-CDK2 complex	IEA
cellular_component	GO:0097135	cyclin E2-CDK2 complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IGI
molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	TAS
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019904	protein domain specific binding	IPI
molecular_function	GO:0030332	cyclin binding	IPI
molecular_function	GO:0035173	histone kinase activity	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0097472	cyclin-dependent protein kinase activity	IDA

Pathways (from Reactome)

Pathway description

G0 and Early G1

Activation of ATR in response to replication stress

Regulation of APC/C activators between G1/S and early anaphase

SCF(Skp2)-mediated degradation of p27/p21

Senescence-Associated Secretory Phenotype (SASP)

DNA Damage/Telomere Stress Induced Senescence

Processing of DNA double-strand break ends

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Regulation of TP53 Activity through Phosphorylation

Regulation of TP53 Degradation

G2 Phase

Orc1 removal from chromatin

Activation of the pre-replicative complex

CDK-mediated phosphorylation and removal of Cdc6

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Cyclin E associated events during G1/S transition

Cyclin A/B1/B2 associated events during G2/M transition

p53-Dependent G1 DNA Damage Response

Cyclin A:Cdk2-associated events at S phase entry

PTK6 Regulates Cell Cycle

Meiotic recombination

Factors involved in megakaryocyte development and platelet production

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000111276	CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B	/ complex / reaction
ENSG00000124762	CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A	/ complex / reaction
ENSG00000097046	CDC7 / O00311 / cell division cycle 7	/ complex / reaction
ENSG00000006634	DBF4 / Q9UBU7 / DBF4 zinc finger	/ complex / reaction
ENSG00000134480	CCNH / P51946 / cyclin H	/ reaction
ENSG00000134508	Q8TDN4 / CABLES1 / Cdk5 and Abl enzyme substrate 1	/ complex / reaction
ENSG00000105173	CCNE1 / P24864 / cyclin E1	/ complex / reaction
ENSG00000094804	CDC6 / Q99741 / cell division cycle 6	/ complex / reaction
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex / reaction
ENSG00000092853	CLSPN / Q9HAW4 / claspin	/ complex / reaction
ENSG00000076242	MLH1 / P40692 / mutL homolog 1	/ complex
ENSG00000135679	MDM2 / Q00987 / MDM2 proto-oncogene	/ reaction
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex / reaction
ENSG00000103479	RBL2 / Q08999 / RB transcriptional corepressor like 2	/ complex / reaction
ENSG00000133740	E2F5 / Q15329 / E2F transcription factor 5	/ complex / reaction
ENSG00000167513	CDT1 / Q9H211 / chromatin licensing and DNA replication factor 1	/ reaction
ENSG00000139687	RB1 / P06400 / RB transcriptional corepressor 1	/ reaction / complex
ENSG00000173207	CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B	/ complex / reaction
ENSG00000175305	CCNE2 / O96020 / cyclin E2	/ complex / reaction
ENSG00000117748	RPA2 / P15927 / replication protein A2	/ complex / reaction
ENSG00000145604	SKP2 / Q13309 / S-phase kinase associated protein 2	/ complex / reaction
ENSG00000105325	FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1	/ reaction / complex
ENSG00000149311	ATM / Q13315 / ATM serine/threonine kinase	/ complex / reaction
ENSG00000141510	TP53 / P04637 / tumor protein p53	/ reaction
ENSG00000101412	E2F1 / Q01094 / E2F transcription factor 1	/ complex / reaction
ENSG00000055130	CUL1 / Q13616 / cullin 1	/ complex / reaction
ENSG00000113558	SKP1 / P63208 / S-phase kinase associated protein 1	/ complex / reaction
ENSG00000112242	E2F3 / O00716 / E2F transcription factor 3	/ complex / reaction
ENSG00000119684	MLH3 / Q9UHC1 / mutL homolog 3	/ complex
ENSG00000080839	RBL1 / P28749 / RB transcriptional corepressor like 1	/ complex / reaction
ENSG00000204086	RPA4 / Q13156 / replication protein A4	/ complex / reaction
ENSG00000205250	E2F4 / Q16254 / E2F transcription factor 4	/ complex / reaction
ENSG00000198176	TFDP1 / Q14186 / transcription factor Dp-1	/ complex / reaction
ENSG00000065328	MCM10 / Q7L590 / minichromosome maintenance 10 replication initiation factor	/ complex / reaction
ENSG00000114126	TFDP2 / Q14188 / transcription factor Dp-2	/ complex / reaction
ENSG00000020426	MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor	/ reaction
ENSG00000093009	CDC45 / O75419 / cell division cycle 45	/ complex / reaction
ENSG00000104320	NBN / nibrin / O60934	/ complex / reaction
ENSG00000134058	CDK7 / P50613 / cyclin dependent kinase 7	/ reaction
ENSG00000166483	WEE1 / P30291 / WEE1 G2 checkpoint kinase	/ complex / reaction
ENSG00000164045	CDC25A / P30304 / cell division cycle 25A	/ reaction
ENSG00000020922	MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease	/ complex / reaction
ENSG00000172977	KAT5 / Q92993 / lysine acetyltransferase 5	/ complex / reaction
ENSG00000101773	RBBP8 / Q99708 / RB binding protein 8, endonuclease	/ complex / reaction
ENSG00000175054	ATR / Q13535 / ATR serine/threonine kinase	/ reaction
ENSG00000113522	RAD50 / Q92878 / RAD50 double strand break repair protein	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr