ENSG00000145604


Homo sapiens

Features
Gene ID: ENSG00000145604
  
Biological name :SKP2
  
Synonyms : Q13309 / SKP2 / S-phase kinase associated protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p13.2
Gene start: 36151989
Gene end: 36184319
  
Corresponding Affymetrix probe sets: 203625_x_at (Human Genome U133 Plus 2.0 Array)   203626_s_at (Human Genome U133 Plus 2.0 Array)   210567_s_at (Human Genome U133 Plus 2.0 Array)   211042_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421941
Ensembl peptide - ENSP00000423188
Ensembl peptide - ENSP00000478031
Ensembl peptide - ENSP00000443492
Ensembl peptide - ENSP00000426675
Ensembl peptide - ENSP00000426004
Ensembl peptide - ENSP00000424234
Ensembl peptide - ENSP00000274254
Ensembl peptide - ENSP00000274255
NCBI entrez gene - 6502     See in Manteia.
OMIM - 601436
RefSeq - XM_017009753
RefSeq - NM_001243120
RefSeq - NM_005983
RefSeq - NM_032637
RefSeq - XM_011514081
RefSeq - XM_011514082
RefSeq - XM_011514083
RefSeq Peptide - NP_005974
RefSeq Peptide - NP_001230049
RefSeq Peptide - NP_116026
swissprot - Q13309
swissprot - A0A0A0MTL5
swissprot - A0A024R069
swissprot - H0Y9I9
swissprot - D6R9R7
swissprot - D6RF40
swissprot - D6RAG5
Ensembl - ENSG00000145604
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skp2ENSDARG00000004937Danio rerio
 SKP2ENSGALG00000003547Gallus gallus
 Skp2ENSMUSG00000054115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071460 cellular response to cell-matrix adhesion IEA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex / reaction
 ENSG00000058056 USP13 / Q92995 / ubiquitin specific peptidase 13  / complex / reaction
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex / reaction
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000070010 UFD1 / Q92890 / ubiquitin recognition factor in ER associated degradation 1  / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction






 

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