ENSDARG00000004937


Danio rerio

Features
Gene ID: ENSDARG00000004937
  
Biological name :skp2
  
Synonyms : skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : Q13309 / Q9Z0Z3 / S-phase kinase associated protein 2 / S-phase kinase-associated protein 2 (p45)
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 22347120
Gene end: 22359336
  
Corresponding Affymetrix probe sets: Dr.25571.1.A1_at (Zebrafish Array)   Dr.4974.1.S1_at (Zebrafish Array)   NM_001082837_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000092527
Ensembl peptide - ENSDARP00000123198
Ensembl peptide - ENSDARP00000120703
Ensembl peptide - ENSDARP00000114755
NCBI entrez gene - 563708     See in Manteia.
RefSeq - NM_001082837
RefSeq Peptide - NP_001076306
swissprot - A3KP53
swissprot - E9QJ20
swissprot - F1QDJ7
swissprot - E9QCZ4
ZFIN ID - ZDB-GENE-030219-158
Ensembl - ENSDARG00000004937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKP2ENSGALG00000003547Gallus gallus
 SKP2ENSG00000145604Homo sapiens
 Skp2ENSMUSG00000054115Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex
 ENSDARG00000015254 fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*  / complex
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / complex / reaction
 ENSDARG00000079198 usp13 / F1QFS9 / ubiquitin specific peptidase 13 / Q92995* / Q5BKP2* / ubiquitin specific peptidase 13 (isopeptidase T-3)*  / complex / reaction
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / complex / reaction
 ENSDARG00000007971 cks1b / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / complex / reaction
 ENSDARG00000010051 ufd1l / ubiquitin recognition factor in ER associated degradation 1 / UFD1* / P70362* / Q92890*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / complex / reaction






 

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