ENSDARG00000040261


Danio rerio

Features
Gene ID: ENSDARG00000040261
  
Biological name :runx2a
  
Synonyms : runt-related transcription factor 2a / runx2a
  
Possible biological names infered from orthology : Q08775 / Q13950 / runt related transcription factor 2 / RUNX2
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 5351922
Gene end: 5516693
  
Corresponding Affymetrix probe sets: DrAffx.2.9.S1_s_at (Zebrafish Array)   NM_212858_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000116368
Ensembl peptide - ENSDARP00000149340
Ensembl peptide - ENSDARP00000096167
NCBI entrez gene - 405784     See in Manteia.
RefSeq - NM_212858
RefSeq Peptide - NP_998023
swissprot - B3DKD9
swissprot - F1R272
ZFIN ID - ZDB-GENE-040629-3
Ensembl - ENSDARG00000040261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RUNX2ENSGALG00000040276Gallus gallus
 RUNX2ENSG00000124813Homo sapiens
 Runx2ENSMUSG00000039153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
runx2b / runt-related transcription factor 2bENSDARG0000005923380
runx1 / runt-related transcription factor 1 / Q01196*ENSDARG0000008764657
runx3 / runt-related transcription factor 3 / Q13761* / Q64131*ENSDARG0000005282656


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IBA
 biological_processGO:0002062 chondrocyte differentiation IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0030097 hemopoiesis IBA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by RUNX2
Regulation of RUNX2 expression and activity
RUNX2 regulates osteoblast differentiation
RUNX2 regulates bone development


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus neuron decreased amount , abnormal
Show

 ZFA:0000737 cranium cranium shape , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003293 sox9a / SRY (sex determining region Y)-box 9a / SOX9* / Q04887* / P48436* / SRY-box 9* / Transcription factor SOX-9 *  / complex / reaction
 ENSDARG00000009273 ppm1da / protein phosphatase, Mg2+/Mn2+ dependent, 1Da / PPM1D* / Q9QZ67* / O15297* / Protein phosphatase 1D * / protein phosphatase, Mg2+/Mn2+ dependent 1D*  / reaction
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000045228 stub1 / STIP1 homology and U-Box containing protein 1 / Q9UNE7* / Q9WUD1*  / complex / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000067976 ar / androgen receptor / P10275* / P19091*  / complex / reaction






 

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