ENSDARG00000052826


Danio rerio

Features
Gene ID: ENSDARG00000052826
  
Biological name :runx3
  
Synonyms : runt-related transcription factor 3 / runx3
  
Possible biological names infered from orthology : Q13761 / Q64131
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 45092766
Gene end: 45225980
  
Corresponding Affymetrix probe sets: Dr.10668.1.S1_a_at (Zebrafish Array)   Dr.10668.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000155932
Ensembl peptide - ENSDARP00000069236
Ensembl peptide - ENSDARP00000117722
Ensembl peptide - ENSDARP00000136974
Ensembl peptide - ENSDARP00000141377
Ensembl peptide - ENSDARP00000146778
NCBI entrez gene - 58127     See in Manteia.
swissprot - F1QZI1
swissprot - F6NM27
swissprot - Q9DEA0
ZFIN ID - ZDB-GENE-000605-2
Ensembl - ENSDARG00000052826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RUNX3ENSGALG00000043372Gallus gallus
 RUNX3ENSG00000020633Homo sapiens
 Runx3ENSMUSG00000070691Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*ENSDARG0000004026159
runx2b / runt-related transcription factor 2bENSDARG0000005923357
runx1 / runt-related transcription factor 1 / Q01196*ENSDARG0000008764652


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IBA
 biological_processGO:0002062 chondrocyte differentiation IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
RUNX3 regulates CDKN1A transcription
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates WNT signaling
RUNX3 regulates YAP1-mediated transcription
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000295 trigeminal ganglion trigeminal ganglion absent , abnormal
trigeminal ganglion increased amount , abnormal
trigeminal ganglion decreased amount , abnormal
Show

 ZFA:0000737 cranium cranium decreased size , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage aplastic , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium aplastic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage aplastic , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage aplastic , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage aplastic , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage aplastic , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage aplastic , abnormal
Show

 ZFA:0001580 neurocranium neurocranium anterior region aplastic , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron absent , abnormal
Rohon-Beard neuron increased amount , abnormal
Rohon-Beard neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / reaction / complex
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000022280 brd2a / bromodomain containing 2a / BRD2* / Q7JJ13* / P25440* / bromodomain containing 2* / Bromodomain-containing protein 2 *  / complex / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / complex / reaction
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / complex / reaction
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / reaction / complex
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / complex / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction






 

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