ENSDARG00000075226


Danio rerio

Features
Gene ID: ENSDARG00000075226
  
Biological name :smad4a
  
Synonyms : smad4a / SMAD family member 4a
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 4 / P97471 / Q13485 / SMAD4 / SMAD family member 4
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 573667
Gene end: 590083
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000097763
Ensembl peptide - ENSDARP00000154736
Ensembl peptide - ENSDARP00000112470
NCBI entrez gene - 559111     See in Manteia.
RefSeq - NM_001122700
RefSeq - XM_017357976
RefSeq Peptide - NP_001116172
swissprot - F1QS48
swissprot - B3DHM7
swissprot - B1PS59
ZFIN ID - ZDB-GENE-990603-8
Ensembl - ENSDARG00000075226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMAD4ENSG00000141646Homo sapiens
 Smad4ENSMUSG00000024515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-222b8.1ENSDARG0000004509472
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042869
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264949
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638933
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193833
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719933
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723833
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609632
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020731
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176321
smad6a / SMAD family member 6aENSDARG0000005320919
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0048264 determination of ventral identity IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0070206 protein trimerization IPI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0071141 SMAD protein complex IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle structure , abnormal
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 ZFA:0000022 floor plate floor plate absent , abnormal
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 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm increased size , abnormal
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 ZFA:0000054 pericardium pericardium structure , abnormal
pericardium edematous , abnormal
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 ZFA:0000114 heart heart decreased size , abnormal
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 ZFA:0000360 heart tube heart tube decreased distribution , abnormal
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 ZFA:0000471 atrium atrium structure , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold absent , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism anterior-posterior axis curved , abnormal
whole organism anterior-posterior axis shortened , abnormal
whole organism anterior region truncated , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001115 trunk trunk apoptotic process increased occurrence , abnormal
trunk curved , abnormal
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 ZFA:0001120 neuroectoderm neuroectoderm wholly dorsalized , abnormal
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 ZFA:0001719 presumptive cardiac ventricle heart tube presumptive cardiac ventricle heart tube decreased distribution , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell increased distribution , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell increased distribution , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016496 cdk8 / cyclin-dependent kinase 8 / P49336* / Q8R3L8*  / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / complex / reaction
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000036685 ccnt2a / cyclin T2a / CCNT2* / O60583* / Q7TQK0* / cyclin T2*  / reaction
 ENSDARG00000044811 cdk9 / cyclin-dependent kinase 9 (CDC2-related kinase) / P50750* / Q99J95* / cyclin dependent kinase 9*  / reaction
 ENSDARG00000000966 ncor2 / nuclear receptor corepressor 2 / Q9WU42* / Q9Y618*  / complex / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSDARG00000016181 trim33 / tripartite motif containing 33 / Q9UPN9*  / complex / reaction
 ENSDARG00000023058 foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *  / complex / reaction
 ENSDARG00000022904 skilb / SKI-like proto-oncogene b / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / complex / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex / reaction
 ENSDARG00000055630 foxh1 / forkhead box H1 / O75593* / O88621* / Forkhead box protein H1 *  / complex / reaction
 ENSDARG00000059337 tgif1 / TGFB-induced factor homeobox 1 / P70284* / Q15583*  / complex / reaction
 ENSDARG00000023933 skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*  / complex / reaction
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / complex / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / complex / reaction
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / complex / reaction
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSDARG00000067719 wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / complex / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / complex / reaction






 

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