ENSDARG00000022904


Danio rerio
domainsmadregulationskilbskisnosuperfamilytranscriptionsignalingpathwaydacputativedna-bindingsand-likec-ski-bindingregulatorsnonski-relatedoncogenernapolymeraseiitransforminggrowthfactorbetareceptorbmpcelldifferentiation

Features
Gene ID: ENSDARG00000022904
  
Biological name :skilb
  
Synonyms : skilb / SKI-like proto-oncogene b
  
Possible biological names infered from orthology : P12757 / Q60665 / SKIL / SKI-like / SKI like proto-oncogene
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 26373341
Gene end: 26386627
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000105507
Ensembl peptide - ENSDARP00000028344
NCBI entrez gene - 100170835     See in Manteia.
RefSeq - NM_001130669
RefSeq Peptide - NP_001124141
swissprot - E7FGJ1
ZFIN ID - ZDB-GENE-080723-40
Ensembl - ENSDARG00000022904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SKILENSGALG00000009356Gallus gallus
 SKILENSG00000136603Homo sapiens
 SkilENSMUSG00000027660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
skila / SKI-like proto-oncogene a / SKIL* / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSDARG0000002393348
skia / v-ski avian sarcoma viral oncogene homolog a / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000004215135
skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*ENSDARG0000000803432
skor1a / SKI family transcriptional corepressor 1a / SKOR1* / P84550* / Q8BX46* / SKI family transcriptional corepressor 1*ENSDARG0000006903018
Q1LXZ9 / skor1b / SKI family transcriptional corepressor 1b / SKOR1* / Q8BX46* / P84550* / SKI family transcriptional corepressor 1*ENSDARG0000006244817
zgc:153395 / SKOR2* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSDARG0000006361413


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028373  Ski-related oncogene Sno


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationresponse to endogenous stimulusresponse to chemicalcellular response to stimuluscellular developmental processanatomical structure developmentnitrogen comnitrogen compound metabolic processbiosyntheticbiosynthetic processcellular metcellular metabolic processprimary metaprimary metabolic processorganic subsorganic substance metabolic processcell communicell communicationresponse to response to endogenous stimulusresponse to response to chemicalcellular rescellular response to stimuluscellular devcellular developmental processanatomical sanatomical structure development
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0045596 negative regulation of cell differentiation IBA
 biological_processGO:0048666 neuron development IBA
 molecular_functionGO:0046332 SMAD binding IBA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000000966 ncor2 / nuclear receptor corepressor 2 / Q9WU42* / Q9Y618*  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction






 

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