ENSDARG00000010207


Danio rerio

Features
Gene ID: ENSDARG00000010207
  
Biological name :smad3b
  
Synonyms : smad3b / SMAD family member 3b
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 3 / P84022 / Q8BUN5 / SMAD3 / SMAD family member 3
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 19772874
Gene end: 19806209
  
Corresponding Affymetrix probe sets: Dr.19379.1.S1_at (Zebrafish Array)   NM_175083_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000043454
NCBI entrez gene - 326283     See in Manteia.
RefSeq - NM_175083
RefSeq Peptide - NP_778258
swissprot - Q66HX9
ZFIN ID - ZDB-GENE-030128-4
Ensembl - ENSDARG00000010207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMAD3ENSGALG00000035701Gallus gallus
 SMAD3ENSG00000166949Homo sapiens
 Smad3ENSMUSG00000032402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609695
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638990
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723867
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719966
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193865
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522641
si:dkey-222b8.1ENSDARG0000004509440
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042840
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264926
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176326
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685825
smad6a / SMAD family member 6aENSDARG0000005320925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000022 floor plate floor plate aplastic , abnormal
floor plate absent , abnormal
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 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm increased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism increased curvature , abnormal
whole organism anterior-posterior axis curved , abnormal
whole organism anterior-posterior axis shortened , abnormal
whole organism anterior region truncated , abnormal
Show

 ZFA:0001114 head head anterior-most region truncated , abnormal
Show

 ZFA:0009248 neuron neuron degenerate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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