ENSDARG00000016858


Danio rerio

Features
Gene ID: ENSDARG00000016858
  
Biological name :smad7
  
Synonyms : smad7 / SMAD family member 7
  
Possible biological names infered from orthology : O15105 / O35253
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 3419459
Gene end: 3452683
  
Corresponding Affymetrix probe sets: Dr.7097.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000024277
Ensembl peptide - ENSDARP00000126001
swissprot - I3ISV6
swissprot - Q8AWR7
ZFIN ID - ZDB-GENE-030128-3
Ensembl - ENSDARG00000016858
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000037160Gallus gallus
 SMAD7BENSGALG00000029545Gallus gallus
 SMAD7ENSG00000101665Homo sapiens
 Smad7ENSMUSG00000025880Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176352
smad6a / SMAD family member 6aENSDARG0000005320949
alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *ENSDARG0000002193829
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719929
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723829
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638928
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020728
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609628
si:dkey-222b8.1ENSDARG0000004509427
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042827
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522627
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of TGF-beta receptor signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000041 mesoderm mesoderm hypoplastic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000135 notochord notochord hypoplastic , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism morphology , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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 ZFA:0005145 muscle muscle hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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