ENSDARG00000021938


Danio rerio

Features
Gene ID: ENSDARG00000021938
  
Biological name :smad9
  
Synonyms : alg5 / smad9 / SMAD family member 9
  
Possible biological names infered from orthology : Mothers against decapentaplegic homolog 9 / O15198 / Q9JIW5
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 34960751
Gene end: 35002459
  
Corresponding Affymetrix probe sets: Dr.3005.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000081548
Ensembl peptide - ENSDARP00000117800
Ensembl peptide - ENSDARP00000131023
Ensembl peptide - ENSDARP00000148074
NCBI entrez gene - 445564     See in Manteia.
RefSeq - NM_001328499
RefSeq - XM_021479160
RefSeq Peptide - NP_001315428
swissprot - F1R0Z7
swissprot - F1QXZ9
ZFIN ID - ZDB-GENE-030131-6586
ZFIN ID - ZDB-GENE-031014-1
Ensembl - ENSDARG00000021938
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMAD9ENSGALG00000017050Gallus gallus
 SMAD9ENSG00000120693Homo sapiens
 Smad9ENSMUSG00000027796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *ENSDARG0000002719979
smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *ENSDARG0000003723879
smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000003609660
smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *ENSDARG0000000638959
smad3b / SMAD family member 3b / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *ENSDARG0000001020759
smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*ENSDARG0000007522638
si:dkey-222b8.1ENSDARG0000004509435
si:dkey-222b8.1 / si:dkey-239n17.4ENSDARG0000007042835
smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *ENSDARG0000003176325
gb:cr929477 / expressed sequence CR929477ENSDARG0000001264924
smad6a / SMAD family member 6aENSDARG0000005320924
smad7 / SMAD family member 7 / O15105* / O35253*ENSDARG0000001685823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR001173  Glycosyltransferase 2-like
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily
 IPR029044  Nucleotide-diphospho-sugar transferases
 IPR035518  Dolichyl-phosphate beta-glucosyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006487 protein N-linked glycosylation IBA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0061515 myeloid cell development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0016740 transferase activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system degenerate , abnormal
Show

 ZFA:0009048 granulocyte granulocyte decreased amount , abnormal
Show

 ZFA:0009141 macrophage macrophage decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000027199 smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000021938 alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *  / complex / reaction
 ENSDARG00000037238 smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *  / complex / reaction
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000075747 zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSDARG00000008034 skib / v-ski avian sarcoma viral oncogene homolog b / SKI* / P12755* / SKI proto-oncogene*  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex / reaction






 

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