Manteia

ENSDARG00000019728

Danio rerio

Features

Gene ID:	ENSDARG00000019728

Biological name :	bmpr1aa

Synonyms :	bmpr1aa / bone morphogenetic protein receptor, type IAa

Possible biological names infered from orthology :	BMPR1A / bone morphogenetic protein receptor type 1A / Bone morphotic protein receptor type-1A / P36894 / P36895

Species:	Danio rerio

Chr. number:	13
Strand:	1
Band:
Gene start:	22555342
Gene end:	22619790

Corresponding Affymetrix probe sets:	Dr.25506.2.A1_at (Zebrafish Array) Dr.25506.3.S1_at (Zebrafish Array) Dr.8154.1.S1_at (Zebrafish Array) NM_131621_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000152766 Ensembl peptide - ENSDARP00000015287 Ensembl peptide - ENSDARP00000150931 NCBI entrez gene - 58145 See in Manteia. RefSeq - NM_131621 RefSeq - XM_005156879 RefSeq - XM_009307349 RefSeq Peptide - NP_571696 swissprot - Q1RLX1 swissprot - B3DJG0 ZFIN ID - ZDB-GENE-000502-1 Ensembl - ENSDARG00000019728

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
BMPR1A	ENSGALG00000002003	Gallus gallus
BMPR1A	ENSG00000107779	Homo sapiens
Bmpr1a	ENSMUSG00000021796	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*	ENSDARG00000105045	81
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...	ENSDARG00000104100	66
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*	ENSDARG00000102742	65
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*	ENSDARG00000017494	47
acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*	ENSDARG00000018968	46
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*	ENSDARG00000042259	46
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*	ENSDARG00000052142	46
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*	ENSDARG00000014986	43
ACVR1C / activin A receptor type 1C / Q8NER5*	ENSDARG00000086172	43
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *	ENSDARG00000018179	41
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*	ENSDARG00000011188	29
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*	ENSDARG00000103108	27
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	ENSDARG00000020057	26
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*	ENSDARG00000034541	26
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*	ENSDARG00000059363	26
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*	ENSDARG00000104700	26
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	ENSDARG00000011941	25
si:dkey-101k6.5	ENSDARG00000055136	25
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*	ENSDARG00000044422	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000333	Ser/Thr protein kinase, TGFB receptor
IPR000472	Activin types I and II receptor domain
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR003605	GS domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001945	lymph vessel development	IGI
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA
biological_process	GO:0009953	dorsal/ventral pattern formation	IGI
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0023014	signal transduction by protein phosphorylation	IEA
biological_process	GO:0030509	BMP signaling pathway	IGI
biological_process	GO:0051260	protein homooligomerization	IDA
biological_process	GO:0060912	cardiac cell fate specification	IGI
biological_process	GO:0060972	left/right pattern formation	IMP
biological_process	GO:0061371	determination of heart left/right asymmetry	IMP
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0070724	BMP receptor complex	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA
molecular_function	GO:0004702	obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

Signaling by BMP

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000094	blood island	blood island decreased size , abnormal	Show
ZFA:0000114	heart	heart orientation whole organism left-right axis, abnormal heart aligned with whole organism central region, abnormal	Show
ZFA:0000360	heart tube	heart tube morphology , abnormal heart tube aligned with whole organism central region, abnormal	Show
ZFA:0001069	ventral fin fold	ventral fin fold decreased size , abnormal	Show
ZFA:0001094	whole organism	whole organism dead , abnormal	Show
ZFA:0001117	post-vent region	post-vent region decreased size , abnormal	Show
ZFA:0001338	intestine	intestine orientation whole organism left-right axis, abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000011188	acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*	/ complex / reaction
ENSDARG00000016086	smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *	/ complex / reaction
ENSDARG00000044422	acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*	/ complex / reaction
ENSDARG00000027199	smad1 / SMAD family member 1 / SMAD5* / Q99717* / P70340* / P97454* / Q15797* / SMAD family member 5* / Mothers against decapentaplegic homolog 5 *	/ complex / reaction
ENSDARG00000019728	bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*	/ complex / reaction
ENSDARG00000021938	alg5 / smad9 / SMAD family member 9 / O15198* / Q9JIW5* / Mothers against decapentaplegic homolog 9 *	/ reaction / complex
ENSDARG00000037238	smad5 / Q9W7E7 / SMAD family member 5 / SMAD1* / Q99717* / P97454* / Q15797* / P70340* / SMAD family member 1* / Mothers against decapentaplegic homolog 5 *	/ reaction / complex
ENSDARG00000011941	bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	/ complex / reaction
ENSDARG00000075747	zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / Q80U44* / zinc finger FYVE-type containing 16*	/ complex / reaction
ENSDARG00000031763	smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *	/ complex / reaction
ENSDARG00000041430	bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*	/ reaction / complex
ENSDARG00000020057	bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*	/ complex / reaction
ENSDARG00000104700	acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*	/ complex / reaction
ENSDARG00000103108	acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*	/ complex / reaction
ENSDARG00000105045	bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*	/ complex / reaction
ENSDARG00000038067	A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr