ENSDARG00000018968


Danio rerio

Features
Gene ID: ENSDARG00000018968
  
Biological name :acvr1ba
  
Synonyms : activin A receptor type 1Ba / acvr1ba
  
Possible biological names infered from orthology : activin A receptor type 1B / Activin receptor type-1B / ACVR1B / P36896 / Q61271
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 27800519
Gene end: 27822920
  
Corresponding Affymetrix probe sets: Dr.3589.1.A1_at (Zebrafish Array)   Dr.5760.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000004431
swissprot - B3DJ37
ZFIN ID - ZDB-GENE-980526-527
Ensembl - ENSDARG00000018968
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACVR1BENSGALG00000029599Gallus gallus
 ACVR1BENSG00000135503Homo sapiens
 Acvr1bENSMUSG00000000532Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*ENSDARG0000005214284
tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*ENSDARG0000004225966
tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*ENSDARG0000001749465
ACVR1C / activin A receptor type 1C / Q8NER5*ENSDARG0000008617261
bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000001972848
bmpr1bb / bone morphogenetic protein receptor, type IBb / BMPR1B* / O00238* / bone morphogenetic protein receptor type 1B*ENSDARG0000010274248
bmpr1ba / bone morphogenetic protein receptor, type IBa / P36898* / O00238* / BMPR1B* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B ...ENSDARG0000010410048
bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSDARG0000010504548
acvr1l / activin A receptor, type 1 like / ACVR1* / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSDARG0000001498646
acvrl1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSDARG0000001817945
acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*ENSDARG0000010310830
acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*ENSDARG0000001118829
tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSDARG0000003454129
si:dkey-101k6.5ENSDARG0000005513628
tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*ENSDARG0000005936328
bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000001194126
acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*ENSDARG0000004442226
bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*ENSDARG0000002005725
acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*ENSDARG0000010470025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001706 endoderm formation IGI
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007493 endodermal cell fate determination IDA
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0031101 fin regeneration IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
brain quality , abnormal
Show

 ZFA:0000029 hindbrain hindbrain morphology , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary structure , abnormal
midbrain hindbrain boundary quality , abnormal
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 ZFA:0000100 cerebellum cerebellum apoptotic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000128 midbrain midbrain apoptotic , abnormal
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 ZFA:0000445 optic tectum optic tectum apoptotic , abnormal
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 ZFA:0001094 whole organism whole organism edematous , abnormal
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 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001259 forebrain ventricle forebrain ventricle increased size , abnormal
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 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
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 ZFA:0001442 upper rhombic lip upper rhombic lip aplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000012671 inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*  / complex / reaction
 ENSDARG00000018968 acvr1ba / activin A receptor type 1Ba / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSDARG00000052142 acvr1bb / activin A receptor type 1Bb / Q61271* / ACVR1B* / P36896* / Activin receptor type-1B * / activin A receptor type 1B*  / complex / reaction
 ENSDARG00000040777 inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000103892 CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction






 

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