ENSDARG00000016086


Danio rerio

Features
Gene ID: ENSDARG00000016086
  
Biological name :smurf1
  
Synonyms : SMAD specific E3 ubiquitin protein ligase 1 / smurf1
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase SMURF1 / Q9CUN6 / Q9HCE7
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 40690212
Gene end: 40768548
  
Corresponding Affymetrix probe sets: Dr.4117.1.A1_at (Zebrafish Array)   NM_001001943_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003721
NCBI entrez gene - 321695     See in Manteia.
RefSeq - NM_001001943
RefSeq - XM_005164115
RefSeq Peptide - NP_001001943
swissprot - F1QEG9
ZFIN ID - ZDB-GENE-040426-2744
Ensembl - ENSDARG00000016086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMURF1ENSGALG00000004655Gallus gallus
 Q9HCE7ENSG00000198742Homo sapiens
 Q9CUN6ENSMUSG00000038780Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *ENSDARG0000003806778
itcha / itchy E3 ubiquitin protein ligase a / ITCH* / Q8C863* / Q96J02* / itchy E3 ubiquitin protein ligase* / E3 ubiquitin-protein ligase Itchy *ENSDARG0000007490340
nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like / Q96PU5* / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase*ENSDARG0000006000639
wwp2 / WW domain containing E3 ubiquitin protein ligase 2 / O00308* / Q9DBH0*ENSDARG0000006134538
wwp1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*ENSDARG0000009753737
itchb / itchy E3 ubiquitin protein ligase b / ITCH* / Q96J02* / itchy E3 ubiquitin protein ligase*ENSDARG0000009919937
hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000000429136
hecw2a / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006244734
si:ch211-188f17.1 / HECW1* / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSDARG0000010095833
nedd4a / neural precursor cell expressed, developmentally down-regulated 4a / NEDD4* / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4* / neural precur...ENSDARG0000009984328
hace1 / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 / Q8IYU2*ENSDARG0000006228027
hecw2b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b / HECW2* / Q9P2P5* / Q6I6G8* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin...ENSDARG0000006325316
LO018629.1 / HECW2* / Q6I6G8* / Q9P2P5* / E3 ubiquitin-protein ligase HECW2 * / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSDARG000001138483


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog on state
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011188 acvr2aa / activin A receptor type 2Aa / P27038* / ACVR2A* / P27037* / Activin receptor type-2A * / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000044422 acvr2ba / activin A receptor type 2Ba / Q13705* / ACVR2B* / P27040* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000019728 bmpr1aa / bone morphogenetic protein receptor, type IAa / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000034541 tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / complex / reaction
 ENSDARG00000042259 tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*  / complex / reaction
 ENSDARG00000059363 tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*  / complex / reaction
 ENSDARG00000011941 bmpr2a / bone morphogenetic protein receptor, type II a (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000017494 tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*  / complex / reaction
 ENSDARG00000041430 bmp2b / bone morphogenetic protein 2b / BMP2* / P21274* / P12643* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSDARG00000020057 bmpr2b / bone morphogenetic protein receptor, type II b (serine/threonine kinase) / BMPR2* / Q13873* / O35607* / Bone morphotic protein receptor type-2 * / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / complex / reaction
 ENSDARG00000104700 acvr2ab / activin A receptor type 2Ab / ACVR2A* / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSDARG00000103108 acvr2bb / activin A receptor type 2Bb / ACVR2B* / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSDARG00000105045 bmpr1ab / bone morphogenetic protein receptor, type IAb / BMPR1A* / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSDARG00000031763 smad6b / SMAD family member 6b / SMAD6* / O43541* / O35182* / SMAD family member 6* / Mothers against decapentaplegic homolog 6 *  / complex






 

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