ENSDARG00000034895


Danio rerio

Features
Gene ID: ENSDARG00000034895
  
Biological name :tgfb1b
  
Synonyms : tgfb1b / transforming growth factor, beta 1b
  
Possible biological names infered from orthology : P01137 / P04202 / TGFB1 / transforming growth factor beta 1
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 21621042
Gene end: 21629828
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000122056
NCBI entrez gene - 563884     See in Manteia.
swissprot - E9QHW0
ZFIN ID - ZDB-GENE-091028-1
Ensembl - ENSDARG00000034895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TGFB1ENSG00000105329Homo sapiens
 Tgfb1ENSMUSG00000002603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150254
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936742
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708742
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187940
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492422
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267121
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475921
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294721
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*ENSDARG0000006913321
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098620
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077719
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799518
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709616
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537816
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052615
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127915
gdf9 / growth differentiation factor 9 / O60383* / Q07105*ENSDARG0000000322914
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430914
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389114
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001078 thymus thymus T cell absent , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016086 smurf1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / complex / reaction
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / reaction
 ENSDARG00000035682 FP102018.1 / Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA. / LTBP3* / Q9NS15* / latent transforming growth factor beta binding protein 3*  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSDARG00000042259 tgfbr1b / transforming growth factor, beta receptor 1 b / P36897* / TGFBR1* / transforming growth factor beta receptor 1*  / complex
 ENSDARG00000055381 bambia / BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a / BAMBI* / Q13145* / Q9D0L6* / BMP and activin membrane bound inhibitor* / BMP and activin membrane-bound inhibi...  / complex / reaction
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000056922 ltbp1 / latent transforming growth factor beta binding protein 1 / Q14766* / Q8CG19*  / complex / reaction
 ENSDARG00000017494 tgfbr1a / transforming growth factor, beta receptor 1 a / Q64729* / TGFBR1* / P36897* / transforming growth factor beta receptor 1* / transforming growth factor, beta receptor I*  / complex
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000007405 strap / serine/threonine kinase receptor associated protein / Q9Y3F4* / Q9Z1Z2*  / complex
 ENSDARG00000034541 tgfbr2b / transforming growth factor beta receptor 2b / Q62312* / TGFBR2* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / complex / reaction
 ENSDARG00000059363 tgfbr2a / transforming growth factor beta receptor 2a / P37173* / TGFBR2* / transforming growth factor beta receptor 2*  / complex / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / complex
 ENSDARG00000101903 zfyve9a / zinc finger, FYVE domain containing 9a / ZFYVE9* / O95405* / zinc finger FYVE-type containing 9* / zinc finger, FYVE domain containing 9*  / complex / reaction
 ENSDARG00000099677 bambib / BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b / BAMBI* / Q13145* / BMP and activin membrane bound inhibitor*  / complex / reaction






 

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