ENSDARG00000070971


Danio rerio

Features
Gene ID: ENSDARG00000070971
  
Biological name :furinb
  
Synonyms : furinb / furin (paired basic amino acid cleaving enzyme) b
  
Possible biological names infered from orthology : FURIN / furin, paired basic amino acid cleaving enzyme / P09958 / P23188
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 8755990
Gene end: 8916917
  
Corresponding Affymetrix probe sets: Dr.13866.1.A1_at (Zebrafish Array)   NM_001045109_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000115357
Ensembl peptide - ENSDARP00000095400
NCBI entrez gene - 566591     See in Manteia.
RefSeq - NM_001045109
RefSeq Peptide - NP_001038574
swissprot - F1QKU2
swissprot - F1Q7B1
ZFIN ID - ZDB-GENE-040901-2
Ensembl - ENSDARG00000070971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FURINENSGALG00000008341Gallus gallus
 FURINENSG00000140564Homo sapiens
 FurinENSMUSG00000030530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000006290970
pcsk5a / proprotein convertase subtilisin/kexin type 5a / PCSK5* / Q92824* / Q04592* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006753742
pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSDARG0000000260038
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945133
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051832
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996829
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000547 mouth mouth open , abnormal
Show

 ZFA:0001058 caudal fin caudal fin morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism decreased length , abnormal
whole organism edematous , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton joint absent , abnormal
Show

 ZFA:0001228 pharyngeal arch 3 skeleton pharyngeal arch 3 skeleton decreased size , abnormal
Show

 ZFA:0001231 pharyngeal arch 4 skeleton pharyngeal arch 4 skeleton decreased size , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
pharyngeal arch cartilage morphology , abnormal
Show

 ZFA:0005473 interhyal-epihyal joint interhyal-epihyal joint absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010097 f9a / coagulation factor IXa / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000058876 mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *  / reaction
 ENSDARG00000026325 mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*  / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000038139 pdgfbb / platelet-derived growth factor beta polypeptide b / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000076900 prozb / protein Z, vitamin K-dependent plasma glycoprotein b / PROZ* / P22891* / Q9CQW3* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000029493 f9b / coagulation factor IXb / F9* / P16294* / P00740* / coagulation factor IX* / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain*  / reaction
 ENSDARG00000037783 proza / protein Z, vitamin K-dependent plasma glycoprotein a / PROZ* / P22891* / protein Z, vitamin K dependent plasma glycoprotein*  / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / reaction
 ENSDARG00000110069 pdgfaa / platelet-derived growth factor alpha polypeptide a / PDGFA* / P04085* / platelet derived growth factor subunit A*  / reaction
 ENSDARG00000086778 pdgfba / platelet-derived growth factor beta polypeptide a / PDGFB* / P01127* / platelet derived growth factor subunit B* / platelet derived growth factor, B polypeptide*  / reaction
 ENSDARG00000088581 f10 / coagulation factor X / O88947* / P00742* / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain*  / reaction
 ENSDARG00000034895 tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*  / reaction
 ENSDARG00000100782 zgc:163025 / F7 (1 of many) / F7* / P08709* / P70375* / coagulation factor VII* / Coagulation factor VII Factor VII light chain Factor VII heavy chain*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr