ENSDARG00000026325


Danio rerio

Features
Gene ID: ENSDARG00000026325
  
Biological name :mmp11a
  
Synonyms : matrix metallopeptidase 11a / mmp11a
  
Possible biological names infered from orthology : matrix metallopeptidase 11 / MMP11 / P24347 / Q02853 / Stromelysin-3
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 30797363
Gene end: 30825415
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000071747
NCBI entrez gene - 563753     See in Manteia.
swissprot - E7FCZ5
ZFIN ID - ZDB-GENE-070817-3
Ensembl - ENSDARG00000026325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP11ENSGALG00000005968Gallus gallus
 MMP11ENSG00000099953Homo sapiens
 Mmp11ENSMUSG00000000901Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mmp11b / matrix metallopeptidase 11b / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*ENSDARG0000001671857
mmp15b / matrix metallopeptidase 15b / MMP15* / P51511* / matrix metallopeptidase 15*ENSDARG0000001307236
mmp24 / matrix metallopeptidase 24 / Q9R0S2* / Q9Y5R2* / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24*ENSDARG0000001889635
mmp14a / matrix metallopeptidase 14a (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *ENSDARG0000000223534
mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *ENSDARG0000000838834
mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *ENSDARG0000005887633
mmp25b / matrix metallopeptidase 25b / MMP25* / Q9NPA2* / matrix metallopeptidase 25*ENSDARG0000001055632
mmp15a / matrix metallopeptidase 15a / MMP15* / O54732* / P51511* / matrix metallopeptidase 15* / Matrix metalloproteinase-15 *ENSDARG0000005196232
mmp25a / matrix metallopeptidase 25a / MMP25* / Q3U435* / Q9NPA2* / matrix metallopeptidase 25* / Matrix metalloproteinase-25 *ENSDARG0000007729031
mmp20a / matrix metallopeptidase 20a (enamelysin) / MMP20* / O60882* / P57748* / matrix metallopeptidase 20* / Matrix metalloproteinase-20 *ENSDARG0000008988731
LO018336.1ENSDARG0000010840131
mmp13a / matrix metallopeptidase 13aENSDARG0000001239530
mmp17a / matrix metallopeptidase 17a / MMP17* / Q9R0S3* / Q9ULZ9* / matrix metallopeptidase 17* / Matrix metalloproteinase-17 *ENSDARG0000007891530
mmp13b / matrix metallopeptidase 13b / MMP13* / P45452* / P33435* / Collagenase 3 * / matrix metallopeptidase 13*ENSDARG0000010079430
mmp13a / matrix metallopeptidase 13aENSDARG0000011445129
mmp30 / matrix metallopeptidase 30 / MMP7* / P09237* / matrix metallopeptidase 7*ENSDARG0000004588728
mmp20b / matrix metallopeptidase 20b (enamelysin)ENSDARG0000005547927
mmp17b / matrix metallopeptidase 17bENSDARG0000010295626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure increased amount , abnormal
Show

 ZFA:0001056 myotome myotome muscle tendon junction increased amount , abnormal
myotome muscle tendon junction spatial pattern , ameliorated
myotome muscle tendon junction amount , ameliorated
myotome muscle tendon junction decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell attachment quality slow muscle cell , ameliorated
slow muscle cell degeneration , ameliorated
Show

 ZFA:0009117 fast muscle cell fast muscle cell muscle tendon junction increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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