ENSMUSG00000000901


Mus musculus

Features
Gene ID: ENSMUSG00000000901
  
Biological name :Mmp11
  
Synonyms : Mmp11 / Q02853 / Stromelysin-3
  
Possible biological names infered from orthology : matrix metallopeptidase 11 / P24347
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 75923222
Gene end: 75936496
  
Corresponding Affymetrix probe sets: 10370037 (MoGene1.0st)   1417234_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151366
Ensembl peptide - ENSMUSP00000000924
Ensembl peptide - ENSMUSP00000112940
Ensembl peptide - ENSMUSP00000116279
Ensembl peptide - ENSMUSP00000120800
NCBI entrez gene - 17385     See in Manteia.
MGI - MGI:97008
RefSeq - NM_008606
RefSeq - XM_017313825
RefSeq - NM_001306184
RefSeq Peptide - NP_001293113
RefSeq Peptide - NP_032632
swissprot - A0A1W2P6R6
swissprot - Q02853
swissprot - Q3UQT3
swissprot - F6QGW1
Ensembl - ENSMUSG00000000901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp11aENSDARG00000026325Danio rerio
 mmp11bENSDARG00000016718Danio rerio
 MMP11ENSGALG00000005968Gallus gallus
 MMP11ENSG00000099953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390336
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761235
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943634
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179034
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361334
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095733
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580033
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822633
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756233
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862032
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308930
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972330
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057830
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032329
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162028
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028705  Stromelysin-3
 IPR033739  Peptidase M10A, catalytic domain
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030574 collagen catabolic process IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1N/Tgfb1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * NIH/Ola

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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