ENSMUSG00000018620


Mus musculus
peptidaseMmp20activitydomainmmatrixextracellularenamelhemopexin-likebindingsuperfamilyzinccatalyticioncollagendegradationpeptidoglycanbinding-likerepeatscysteineswitchsitemetalloproteinase-pgbd-likeproteolysisdisassemblyproteincatabolicprocessamelogenesis

Features
Gene ID: ENSMUSG00000018620
  
Biological name :Mmp20
  
Synonyms : Matrix metalloproteinase-20 / Mmp20 / P57748
  
Possible biological names infered from orthology : matrix metallopeptidase 20 / O60882
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 7628231
Gene end: 7674979
  
Corresponding Affymetrix probe sets: 10583122 (MoGene1.0st)   1421706_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034487
NCBI entrez gene - 30800     See in Manteia.
MGI - MGI:1353466
RefSeq - NM_013903
RefSeq Peptide - NP_038931
swissprot - P57748
Ensembl - ENSMUSG00000018620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp20aENSDARG00000089887Danio rerio
 MMP20ENSG00000137674Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361345
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756245
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057845
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580043
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032343
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972340
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162038
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308938
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761237
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095736
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822635
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179035
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390334
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943633
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090132
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028716  Matrix metalloproteinase-20
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcatabolic processanatomical structure developmentnitrogen compound metabnitrogen compound metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processcellular component orgacellular component organizationcatabolic processcatabolic processanatomical structure deanatomical structure development
catalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion binding
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0097186 amelogenesis IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures


Phenotype (from MGI, Zfin or HPO)
skeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypecraniofacial phenotypegrowth/size phenotypeskeleton phenotypeskeleton phenotypecraniofacial phenotypecraniofacial phenotypegrowth/size phenotypegrowth/size phenotype
IDPhenotypeDefinition Genetic BG
 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002648 delaminated enamel 
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002649 abnormal enamel rod pattern "anomalous orientation of the structural unit of tooth enamel " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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