Manteia

ENSMUSG00000029436

Mus musculus

Features

Gene ID:	ENSMUSG00000029436

Biological name :	Mmp17

Synonyms :	Matrix metalloproteinase-17 / Mmp17 / Q9R0S3

Possible biological names infered from orthology :	matrix metallopeptidase 17 / Q9ULZ9

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	G1.3
Gene start:	129584169
Gene end:	129611099

Corresponding Affymetrix probe sets:	10526038 (MoGene1.0st) 1448598_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031390 NCBI entrez gene - 23948 See in Manteia. MGI - MGI:1346076 RefSeq - NM_011846 RefSeq Peptide - NP_035976 swissprot - Q9R0S3 Ensembl - ENSMUSG00000029436

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mmp17a	ENSDARG00000078915	Danio rerio
MMP17	ENSG00000198598	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*	ENSMUSG00000023903	45
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*	ENSMUSG00000031790	35
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*	ENSMUSG00000000957	34
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*	ENSMUSG00000027612	33
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*	ENSMUSG00000028226	33
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*	ENSMUSG00000000901	29
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*	ENSMUSG00000005800	29
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*	ENSMUSG00000018620	28
Mmp3 / matrix metallopeptidase 3	ENSMUSG00000043613	28
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*	ENSMUSG00000047562	28
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*	ENSMUSG00000050578	28
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*	ENSMUSG00000043089	26
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*	ENSMUSG00000049723	26
Mmp27 / matrix metallopeptidase 27 / Q9H306*	ENSMUSG00000070323	26
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*	ENSMUSG00000041620	25
Mmp7 / matrix metallopeptidase 7 / P09237*	ENSMUSG00000018623	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000585	Hemopexin-like domain
IPR001818	Peptidase M10, metallopeptidase
IPR002477	Peptidoglycan binding-like
IPR006026	Peptidase, metallopeptidase
IPR018487	Hemopexin-like repeats
IPR021190	Peptidase M10A
IPR024079	Metallopeptidase, catalytic domain superfamily
IPR028726	Matrix metalloproteinase-17
IPR033739	Peptidase M10A, catalytic domain
IPR036365	PGBD-like superfamily
IPR036375	Hemopexin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001822	kidney development	IMP
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0042756	drinking behavior	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
cellular_component	GO:0031225	anchored component of membrane	IEA
molecular_function	GO:0004222	metalloendopeptidase activity	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008237	metallopeptidase activity	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Activation of Matrix Metalloproteinases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Selp^tm1Bay/Selp^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003620	decreased urine output	"decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0004193	abnormal kidney papilla morphology	"any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0008055	increased urine osmolality	"increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0010981	abnormal branching involved in ureteric bud morphogenesis	"anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0011737	hypodipsia	"abnormally diminished thirst with a consequential reduction of fluid intake; often related to dysfunction of the thirst osmoreceptor in the anterior hypothalamus" [MGI:anna]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo
MP:0011942	decreased fluid intake	"reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Clnk^tm1Rygo/Clnk^tm1Rygo Genetic Background: B6.129P2-Clnk^tm1Rygo

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr