ENSDARG00000008388


Danio rerio

Features
Gene ID: ENSDARG00000008388
  
Biological name :mmp14b
  
Synonyms : matrix metallopeptidase 14b (membrane-inserted) / mmp14b
  
Possible biological names infered from orthology : matrix metallopeptidase 14 / Matrix metalloproteinase-14 / MMP14 / P50281 / P53690
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 38161318
Gene end: 38183641
  
Corresponding Affymetrix probe sets: Dr.23324.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000044263
NCBI entrez gene - 566945     See in Manteia.
RefSeq - NM_194414
RefSeq Peptide - NP_919395
swissprot - B0R0I1
ZFIN ID - ZDB-GENE-030901-2
Ensembl - ENSDARG00000008388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP14ENSG00000157227Homo sapiens
 Mmp14ENSMUSG00000000957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mmp14a / matrix metallopeptidase 14a (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *ENSDARG0000000223565
mmp15b / matrix metallopeptidase 15b / MMP15* / P51511* / matrix metallopeptidase 15*ENSDARG0000001307253
mmp24 / matrix metallopeptidase 24 / Q9R0S2* / Q9Y5R2* / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24*ENSDARG0000001889648
mmp15a / matrix metallopeptidase 15a / MMP15* / O54732* / P51511* / matrix metallopeptidase 15* / Matrix metalloproteinase-15 *ENSDARG0000005196247
mmp16b / matrix metallopeptidase 16b (membrane-inserted) / MMP16* / P51512* / Q9WTR0* / matrix metallopeptidase 16* / Matrix metalloproteinase-16 *ENSDARG0000005887646
mmp25b / matrix metallopeptidase 25b / MMP25* / Q9NPA2* / matrix metallopeptidase 25*ENSDARG0000001055632
mmp25a / matrix metallopeptidase 25a / MMP25* / Q3U435* / Q9NPA2* / matrix metallopeptidase 25* / Matrix metalloproteinase-25 *ENSDARG0000007729029
mmp17a / matrix metallopeptidase 17a / MMP17* / Q9R0S3* / Q9ULZ9* / matrix metallopeptidase 17* / Matrix metalloproteinase-17 *ENSDARG0000007891528
mmp13a / matrix metallopeptidase 13aENSDARG0000001239527
mmp13b / matrix metallopeptidase 13b / MMP13* / P45452* / P33435* / Collagenase 3 * / matrix metallopeptidase 13*ENSDARG0000010079427
mmp13a / matrix metallopeptidase 13aENSDARG0000011445127
mmp11a / matrix metallopeptidase 11a / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*ENSDARG0000002632526
mmp30 / matrix metallopeptidase 30 / MMP7* / P09237* / matrix metallopeptidase 7*ENSDARG0000004588726
mmp11b / matrix metallopeptidase 11b / MMP11* / P24347* / Q02853* / Stromelysin-3 * / matrix metallopeptidase 11*ENSDARG0000001671825
mmp20b / matrix metallopeptidase 20b (enamelysin)ENSDARG0000005547924
mmp20a / matrix metallopeptidase 20a (enamelysin) / MMP20* / O60882* / P57748* / matrix metallopeptidase 20* / Matrix metalloproteinase-20 *ENSDARG0000008988724
mmp17b / matrix metallopeptidase 17bENSDARG0000010295624
LO018336.1ENSDARG0000010840123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033739  Peptidase M10A, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009948 anterior/posterior axis specification IMP
 biological_processGO:0030010 establishment of cell polarity IGI
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060026 convergent extension IGI
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity NAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
axis increased width , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000109 forebrain forebrain increased width , abnormal
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 ZFA:0000135 notochord notochord increased width , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0001064 rhombomere rhombomere increased width , abnormal
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 ZFA:0001065 lateral mesoderm lateral mesoderm morphology , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism morphology , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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 ZFA:0001500 auditory capsule auditory capsule morphology , abnormal
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 ZFA:0009138 mesodermal cell mesodermal cell circular , abnormal
mesodermal cell disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008388 mmp14b / matrix metallopeptidase 14b (membrane-inserted) / MMP14* / P50281* / P53690* / matrix metallopeptidase 14* / Matrix metalloproteinase-14 *  / reaction
 ENSDARG00000075261 timp2b / TIMP metallopeptidase inhibitor 2b / TIMP2* / P16035* / TIMP metallopeptidase inhibitor 2*  / reaction / complex
 ENSDARG00000062909 furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSDARG00000070971 furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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