ENSDARG00000067537


Danio rerio

Features
Gene ID: ENSDARG00000067537
  
Biological name :pcsk5a
  
Synonyms : pcsk5a / proprotein convertase subtilisin/kexin type 5a
  
Possible biological names infered from orthology : PCSK5 / proprotein convertase subtilisin/kexin type 5 / Q04592 / Q92824
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 55265274
Gene end: 55349429
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000079749
Ensembl peptide - ENSDARP00000104646
swissprot - A2BHH6
swissprot - F1R175
ZFIN ID - ZDB-GENE-060531-130
Ensembl - ENSDARG00000067537
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000015164Gallus gallus
 ENSGALG00000033256Gallus gallus
 PCSK5ENSG00000099139Homo sapiens
 Pcsk5ENSMUSG00000024713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pcsk5b / proprotein convertase subtilisin/kexin type 5b / PCSK5* / Q92824* / proprotein convertase subtilisin/kexin type 5*ENSDARG0000006051825
furina / furin (paired basic amino acid cleaving enzyme) a / FURIN* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000006290919
furinb / furin (paired basic amino acid cleaving enzyme) b / FURIN* / P23188* / P09958* / furin, paired basic amino acid cleaving enzyme*ENSDARG0000007097119
pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *ENSDARG0000000260016
pcsk2 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSDARG0000001945114
pcsk7 / proprotein convertase subtilisin/kexin type 7 / Q16549*ENSDARG0000006996814
pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSDARG0000010457412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR000742  EGF-like domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032778  Growth factor receptor domain 4
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0048899 anterior lateral line development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
NGF processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000243 neuromast neuromast decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001469 lateral line lateral line morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr