ENSDARG00000023058


Danio rerio

Features
Gene ID: ENSDARG00000023058
  
Biological name :foxo3a
  
Synonyms : forkhead box O3A / foxo3a
  
Possible biological names infered from orthology : forkhead box O3 / Forkhead box protein O3 / FOXO3 / O43524 / Q9WVH4
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 6793001
Gene end: 6810785
  
Corresponding Affymetrix probe sets: Dr.14771.1.S1_at (Zebrafish Array)   Dr.14771.2.S1_at (Zebrafish Array)   Dr.14771.2.S1_x_at (Zebrafish Array)   NM_001009988_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000036177
NCBI entrez gene - 494532     See in Manteia.
RefSeq - NM_001009988
RefSeq Peptide - NP_001009988
swissprot - Q5I0F7
ZFIN ID - ZDB-GENE-050116-1
Ensembl - ENSDARG00000023058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXO3ENSGALG00000015297Gallus gallus
 FOXO3ENSG00000118689Homo sapiens
 Foxo3ENSMUSG00000048756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxo3b / forkhead box O3b / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *ENSDARG0000004290455
foxo6b / forkhead box O6 b / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *ENSDARG0000002461938
A3RK74 / foxo1a / forkhead box O1 a / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *ENSDARG0000009955538
foxo4 / forkhead box O4 / P98177* / Q9WVH3* / Forkhead box protein O4 *ENSDARG0000005579237
A3RK75 / foxo1b / forkhead box O1 b / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *ENSDARG0000006154936
foxo6a / forkhead box O6 a / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *ENSDARG0000010048630
foxm1 / forkhead box M1 / Q08050*ENSDARG0000000320014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0051960 regulation of nervous system development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
AKT phosphorylates targets in the nucleus
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain V-shaped , abnormal
Show

 ZFA:0001114 head head malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036096 smad3a / SMAD family member 3a / SMAD3* / Q8BUN5* / P84022* / SMAD family member 3* / Mothers against decapentaplegic homolog 3 *  / complex / reaction
 ENSDARG00000006389 smad2 / Q9I9P9 / SMAD family member 2 / Q62432* / Q15796* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSDARG00000075226 smad4a / SMAD family member 4a / SMAD4* / Q13485* / SMAD family member 4*  / complex / reaction
 ENSDARG00000028082 mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*  / reaction






 

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