ENSDARG00000042904


Danio rerio

Features
Gene ID: ENSDARG00000042904
  
Biological name :foxo3b
  
Synonyms : forkhead box O3b / foxo3b
  
Possible biological names infered from orthology : forkhead box O3 / Forkhead box protein O3 / FOXO3 / O43524 / Q9WVH4
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 32286765
Gene end: 32332736
  
Corresponding Affymetrix probe sets: Dr.8209.1.S1_at (Zebrafish Array)   Dr.8209.1.S2_at (Zebrafish Array)   NM_131085_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000062981
NCBI entrez gene - 30296     See in Manteia.
RefSeq - NM_131085
RefSeq Peptide - NP_571160
swissprot - Q5TYS1
ZFIN ID - ZDB-GENE-990708-6
Ensembl - ENSDARG00000042904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXO3ENSGALG00000015297Gallus gallus
 FOXO3ENSG00000118689Homo sapiens
 Foxo3ENSMUSG00000048756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *ENSDARG0000002305854
A3RK74 / foxo1a / forkhead box O1 a / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *ENSDARG0000009955539
foxo6b / forkhead box O6 b / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *ENSDARG0000002461937
A3RK75 / foxo1b / forkhead box O1 b / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *ENSDARG0000006154936
foxo4 / forkhead box O4 / P98177* / Q9WVH3* / Forkhead box protein O4 *ENSDARG0000005579235
foxo6a / forkhead box O6 a / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *ENSDARG0000010048631
foxm1 / forkhead box M1 / Q08050*ENSDARG0000000320015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2
 IPR032067  FOXO protein, transactivation domain
 IPR032068  FOXO protein, KIX-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IPI
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0060215 primitive hemopoiesis IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
AKT phosphorylates targets in the nucleus
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased amount , abnormal
whole organism increased amount , abnormal
whole organism decreased life span , abnormal
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 ZFA:0001114 head head decreased thickness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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