Manteia

ENSDARG00000099555

Danio rerio

Features

Gene ID:	ENSDARG00000099555

Biological name :	foxo1a

Synonyms :	A3RK74 / forkhead box O1 a / foxo1a

Possible biological names infered from orthology :	forkhead box O1 / Forkhead box protein O1 / FOXO1 / Q12778 / Q9R1E0

Species:	Danio rerio

Chr. number:	15
Strand:	1
Band:
Gene start:	3284416
Gene end:	3379041

Corresponding Affymetrix probe sets:	Dr.16210.1.A1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000155088 Ensembl peptide - ENSDARP00000134884 Ensembl peptide - ENSDARP00000150164 NCBI entrez gene - 768121 See in Manteia. RefSeq - NM_001077257 RefSeq - XM_009291427 RefSeq Peptide - NP_001070725 swissprot - Q08BL0 swissprot - A3RK74 ZFIN ID - ZDB-GENE-061013-59 Ensembl - ENSDARG00000099555

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
A3RK75 / foxo1b / forkhead box O1 b / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *	ENSDARG00000061549	61
foxo3b / forkhead box O3b / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *	ENSDARG00000042904	39
foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *	ENSDARG00000023058	37
foxo6b / forkhead box O6 b / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *	ENSDARG00000024619	36
foxo4 / forkhead box O4 / P98177* / Q9WVH3* / Forkhead box protein O4 *	ENSDARG00000055792	35
foxo6a / forkhead box O6 a / FOXO6* / A8MYZ6* / Q70KY4* / forkhead box O6* / Forkhead box protein O6 *	ENSDARG00000100486	30
foxm1 / forkhead box M1 / Q08050*	ENSDARG00000003200	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR001766	Fork head domain
IPR011991	ArsR-like helix-turn-helix domain
IPR030456	Fork head domain conserved site 2
IPR032067	FOXO protein, transactivation domain
IPR032068	FOXO protein, KIX-binding domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001945	lymph vessel development	IGI
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0009653	anatomical structure morphogenesis	IBA
biological_process	GO:0030154	cell differentiation	IBA
biological_process	GO:0048659	smooth muscle cell proliferation	IMP
biological_process	GO:0048745	smooth muscle tissue development	IMP
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IBA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

AKT phosphorylates targets in the nucleus

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000041	mesoderm	mesoderm decreased amount , abnormal	Show
ZFA:0000112	gut	gut anatomical region decreased amount , abnormal	Show
ZFA:0000121	lateral plate mesoderm	lateral plate mesoderm cell proliferation decreased occurrence , abnormal	Show
ZFA:0001338	intestine	intestine smooth muscle cell decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000028082	mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr