ENSDARG00000028082


Danio rerio

Features
Gene ID: ENSDARG00000028082
  
Biological name :mapkapk5
  
Synonyms : mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5
  
Possible biological names infered from orthology : Gm42878 / MAP kinase-activated protein kinase 5 / O54992 / Q8IW41
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 69553686
Gene end: 69571572
  
Corresponding Affymetrix probe sets: Dr.17304.1.A1_at (Zebrafish Array)   NM_001002336_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113922
NCBI entrez gene - 436608     See in Manteia.
RefSeq - NM_001002336
RefSeq Peptide - NP_001002336
swissprot - A2BGS0
swissprot - Q6DHN7
ZFIN ID - ZDB-GENE-040718-25
Ensembl - ENSDARG00000028082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPKAPK5ENSGALG00000004743Gallus gallus
 Q8IW41ENSG00000089022Homo sapiens
 Gm42878ENSMUSG00000105340Mus musculus
 O54992ENSMUSG00000029454Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...ENSDARG0000000255233
mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...ENSDARG0000001853032
mapkapk3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644*ENSDARG0000011161232
mknk2a / MAP kinase interacting serine/threonine kinase 2a / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001137324
mknk2b / MAP kinase interacting serine/threonine kinase 2b / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001516424
mknk1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSDARG0000001841123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000110581 mapk4 / mitogen-activated protein kinase 4 / P31152* / Q6P5G0*  / complex / reaction
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000032103 mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*  / complex / reaction
 ENSDARG00000059125 prkacbb / protein kinase, cAMP-dependent, catalytic, beta b / P22694* / PRKACB* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSDARG00000023058 foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000061549 A3RK75 / foxo1b / forkhead box O1 b / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *  / reaction
 ENSDARG00000052783 cdc42ep3 / CDC42 effector protein (Rho GTPase binding) 3 / Q9UKI2* / CDC42 effector protein 3*  / reaction
 ENSDARG00000062390 cdc42ep5 / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / Q9Z0X0* / 1700027J19Rik* / CDC42 effector protein 5*  / reaction
 ENSDARG00000041065 hspb1 / heat shock protein, alpha-crystallin-related, 1 / P14602* / P04792* / Heat shock protein beta-1 * / heat shock protein family B (small) member 1*  / reaction
 ENSDARG00000053959 cdc42ep2 / CDC42 effector protein (Rho GTPase binding) 2 / O14613* / Q8JZX9* / CDC42 effector protein 2*  / reaction
 ENSDARG00000099555 A3RK74 / foxo1a / forkhead box O1 a / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *  / reaction
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

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