ENSDARG00000101637


Danio rerio

Features
Gene ID: ENSDARG00000101637
  
Biological name :ccnd1
  
Synonyms : ccnd1 / cyclin D1 / Q90459
  
Possible biological names infered from orthology : G1/S-specific cyclin-D1 / P24385 / P25322
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 54668303
Gene end: 54679595
  
Corresponding Affymetrix probe sets: Dr.24753.1.S1_at (Zebrafish Array)   Dr.24753.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000129985
Ensembl peptide - ENSDARP00000140550
Ensembl peptide - ENSDARP00000134435
Ensembl peptide - ENSDARP00000133850
NCBI entrez gene - 30222     See in Manteia.
swissprot - A7YYE4
swissprot - A0A0R4IEY8
swissprot - A0A0R4IAQ3
swissprot - Q90459
ZFIN ID - ZDB-GENE-980526-176
Ensembl - ENSDARG00000101637
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCND1ENSGALG00000007555Gallus gallus
 CCND1ENSG00000110092Homo sapiens
 Ccnd1ENSMUSG00000070348Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ccnd2a / cyclin D2, a / CCND2* / P30279* / P30280* / cyclin D2* / G1/S-specific cyclin-D2 *ENSDARG0000005174863
ccnd2b / cyclin D2, b / CCND2* / P30279* / P30280* / cyclin D2* / G1/S-specific cyclin-D2 *ENSDARG0000007040857
ccnd3 / cyclin D3 / P30281* / P30282* / G1/S-specific cyclin-D3 *ENSDARG0000002739139
si:ch211-152f23.5ENSDARG0000001974135
ccne1 / cyclin E1 / P24864* / Q61457* / G1/S-specific cyclin-E1 *ENSDARG0000009862225
ccne2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *ENSDARG0000009852923
ccna2 / cyclin A2 / P20248*ENSDARG0000001109421
ccnb3 / cyclin B3 / Q8WWL7*ENSDARG0000003485520
ccna1 / cyclin A1 / P78396* / Q61456*ENSDARG0000004323620
ccnb2 / cyclin B2 / O95067* / P30276* / G2/mitotic-specific cyclin-B2 *ENSDARG0000003618018
ccnb1 / cyclin B1 / P14635* / P24860* / G2/mitotic-specific cyclin-B1 *ENSDARG0000005192316
FQ311924.1 / CCNO* / P22674* / cyclin O*ENSDARG0000009954216


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR015451  Cyclin D


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle ISS
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint ISS
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061074 regulation of neural retina development IGI
 biological_processGO:0070050 neuron cellular homeostasis IMP
 biological_processGO:0071157 negative regulation of cell cycle arrest ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0017053 transcriptional repressor complex ISS
 molecular_functionGO:0003714 transcription corepressor activity ISS


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Regulation of RUNX1 Expression and Activity
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000152 retina retina cell decreased amount , abnormal
retina absent , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer decreased thickness , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell amount , ameliorated
Show

 ZFA:0009262 retinal cone cell retinal cone cell amount , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007657 ccnh / cyclin H / P51946* / Q61458*  / reaction
 ENSDARG00000002077 mnat1 / MNAT CDK-activating kinase assembly factor 1 / P51949* / P51948* / CDK-activating kinase assembly factor MAT1 * / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000022280 brd2a / bromodomain containing 2a / BRD2* / Q7JJ13* / P25440* / bromodomain containing 2* / Bromodomain-containing protein 2 *  / reaction / complex
 ENSDARG00000051916 cdk7 / cyclin-dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / reaction / complex
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / complex / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / reaction
 ENSDARG00000070228 cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*  / complex / reaction
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / reaction
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / complex / reaction






 

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