ENSDARG00000054271


Danio rerio

Features
Gene ID: ENSDARG00000054271
  
Biological name :cdkn1bb
  
Synonyms : cdkn1bb / cyclin-dependent kinase inhibitor 1Bb
  
Possible biological names infered from orthology : CDKN1B / cyclin dependent kinase inhibitor 1B / P46414 / P46527
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 2282265
Gene end: 2287189
  
Corresponding Affymetrix probe sets: Dr.12605.1.S1_at (Zebrafish Array)   Dr.9024.1.A1_at (Zebrafish Array)   NM_212792_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000070891
NCBI entrez gene - 368329     See in Manteia.
RefSeq - NM_212792
RefSeq Peptide - NP_997957
swissprot - Q90YX4
ZFIN ID - ZDB-GENE-030521-13
Ensembl - ENSDARG00000054271
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDKN1BENSGALG00000022980Gallus gallus
 CDKN1BENSG00000111276Homo sapiens
 Cdkn1bENSMUSG00000003031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*ENSDARG0000002901836
cdkn1ca / cyclin-dependent kinase inhibitor 1Ca / P49919* / P49918* / CDKN1C* / cyclin dependent kinase inhibitor 1C* / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA.*ENSDARG0000001087825
cdkn1cb / cyclin-dependent kinase inhibitor 1Cb / P49919* / P49918* / CDKN1C* / cyclin dependent kinase inhibitor 1C* / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA.*ENSDARG0000010490323
cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *ENSDARG0000007655417


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029843  Cyclin-dependent kinase inhibitor 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel nucleus increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007657 ccnh / cyclin H / P51946* / Q61458*  / reaction
 ENSDARG00000002077 mnat1 / MNAT CDK-activating kinase assembly factor 1 / P51949* / P51948* / CDK-activating kinase assembly factor MAT1 * / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSDARG00000051916 cdk7 / cyclin-dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000007971 cks1b / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / complex / reaction
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / reaction
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / complex / reaction
 ENSDARG00000070228 cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*  / complex / reaction
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / complex / reaction






 

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