ENSDARG00000033443


Danio rerio

Features
Gene ID: ENSDARG00000033443
  
Biological name :mdm2
  
Synonyms : mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase Mdm2 / MDM2 proto-oncogene / P23804 / Q00987
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 23125689
Gene end: 23136195
  
Corresponding Affymetrix probe sets: Dr.542.1.S1_at (Zebrafish Array)   NM_131364_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108555
Ensembl peptide - ENSDARP00000147328
Ensembl peptide - ENSDARP00000138060
Ensembl peptide - ENSDARP00000116463
Ensembl peptide - ENSDARP00000072320
NCBI entrez gene - 30637     See in Manteia.
RefSeq - NM_131364
RefSeq Peptide - NP_571439
swissprot - A0A0R4ISQ1
swissprot - B0R0S9
swissprot - F6NS64
swissprot - B0R0S8
ZFIN ID - ZDB-GENE-990415-153
Ensembl - ENSDARG00000033443
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MDM2ENSGALG00000009942Gallus gallus
 MDM2ENSG00000135679Homo sapiens
 Mdm2ENSMUSG00000020184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mdm4 / MDM4, p53 regulator / O15151*ENSDARG0000005751323


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR001876  Zinc finger, RanBP2-type
 IPR003121  SWIB/MDM2 domain
 IPR015459  Ubiquitin-protein ligase E3 MDM2
 IPR016495  p53 negative regulator Mdm2/Mdm4
 IPR028340  E3 ubiquitin-protein ligase Mdm2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye malformed , abnormal
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 ZFA:0000396 nervous system nervous system apoptotic , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism increased amount , abnormal
whole organism apoptotic , abnormal
whole organism dead , abnormal
whole organism apoptotic process increased occurrence , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head discolored , abnormal
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 ZFA:0001115 trunk trunk shortened , abnormal
trunk increased amount , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
pronephric tubule epithelial cell apoptotic , abnormal
pronephric tubule epithelial cell decreased amount , abnormal
Show

 ZFA:0005283 renal capsular space renal capsular space dilated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / complex / reaction
 ENSDARG00000025522 sgk1 / Q7ZTW4 / serum/glucocorticoid regulated kinase 1 / Q9WVC6* / O00141* / Serine/threonine-protein kinase Sgk1 *  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000073710 usp7 / ubiquitin specific peptidase 7 (herpes virus-associated) / Q93009* / ubiquitin specific peptidase 7*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / complex / reaction
 ENSDARG00000037262 cdkn2a/b / cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) / CDKN2A* / CDKN2B* / P42772* / P55271* / Q8N726* / P42771* / cyclin dependent kinase inhibitor 2A* / cyclin dependent...  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000059083 ppp2r5ca / protein phosphatase 2, regulatory subunit B, gamma a / Q13362* / PPP2R5C* / protein phosphatase 2 regulatory subunit Bgamma*  / complex
 ENSDARG00000031200 ppp2r5cb / protein phosphatase 2, regulatory subunit B, gamma b / Q60996* / Q13362* / PPP2R5C* / protein phosphatase 2 regulatory subunit Bgamma* / protein phosphatase 2, regulatory subunit B, gamma*  / complex
 ENSDARG00000057513 mdm4 / MDM4, p53 regulator / O15151*  / complex / reaction
 ENSDARG00000000729 daxx / death-domain associated protein / Q9UER7* / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction






 

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