ENSDARG00000037262


Danio rerio

Features
Gene ID: ENSDARG00000037262
  
Biological name :cdkn2a/b
  
Synonyms : cdkn2a/b / cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
  
Possible biological names infered from orthology : CDKN2A / CDKN2B / Cyclin-dependent kinase 4 inhibitor B / cyclin dependent kinase inhibitor 2A / cyclin dependent kinase inhibitor 2B / P42771 / P42772 / P55271 / Q8N726
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 26127818
Gene end: 26131088
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000054208
Ensembl peptide - ENSDARP00000145630
NCBI entrez gene - 100329528     See in Manteia.
swissprot - E9QFU2
ZFIN ID - ZDB-GENE-081104-306
Ensembl - ENSDARG00000037262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDKN2BENSGALG00000026137Gallus gallus
 CDKN2AENSG00000147889Homo sapiens
 CDKN2BENSG00000147883Homo sapiens
 Cdkn2bENSMUSG00000073802Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdkn2c / cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) / P42773* / Q60772* / cyclin dependent kinase inhibitor 2C* / Cyclin-dependent kinase 4 inhibitor C *ENSDARG0000005761043
cdkn2d / cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) / P55273* / Q60773* / cyclin dependent kinase inhibitor 2D* / Cyclin-dependent kinase 4 inhibitor D *ENSDARG0000009417643


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Regulation of TP53 Degradation
Cyclin D associated events in G1
Stabilization of p53
Regulation of RUNX3 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000100 cerebellum cerebellum decreased volume , abnormal
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 ZFA:0000109 forebrain forebrain decreased volume , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / complex / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSDARG00000057513 mdm4 / MDM4, p53 regulator / O15151*  / complex / reaction
 ENSDARG00000070228 cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*  / complex / reaction






 

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