ENSDARG00000014571


Danio rerio

Features
Gene ID: ENSDARG00000014571
  
Biological name :ctnnb1
  
Synonyms : catenin (cadherin-associated protein), beta 1 / ctnnb1
  
Possible biological names infered from orthology : catenin beta 1 / P35222 / Q02248
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 6182501
Gene end: 6205790
  
Corresponding Affymetrix probe sets: Dr.10259.1.S1_at (Zebrafish Array)   Dr.10259.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000032935
Ensembl peptide - ENSDARP00000139205
NCBI entrez gene - 30265     See in Manteia.
RefSeq - NM_131059
RefSeq Peptide - NP_571134
swissprot - F1QGH7
swissprot - A0A0N4SUA5
ZFIN ID - ZDB-GENE-980526-362
Ensembl - ENSDARG00000014571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTNNB1ENSGALG00000037203Gallus gallus
 CTNNB1ENSG00000168036Homo sapiens
 Ctnnb1ENSMUSG00000006932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ctnnb2 / catenin, beta 2ENSDARG0000002347292
jupa / junction plakoglobin a / JUP* / P14923* / Q02257* / junction plakoglobin*ENSDARG0000007078761
jupb / junction plakoglobin b / JUP* / P14923* / Q02257* / junction plakoglobin*ENSDARG0000005906760


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR013284  Beta-catenin
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IMP
 biological_processGO:0001889 liver development IGI
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0007155 cell adhesion IC
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007398 ectoderm development IGI
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0034333 adherens junction assembly IEA
 biological_processGO:0048262 determination of dorsal/ventral asymmetry IMP
 biological_processGO:0060026 convergent extension IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005915 zonula adherens IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016342 catenin complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IBA
 molecular_functionGO:0045294 alpha-catenin binding IBA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
CDO in myogenesis
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Adherens junctions interactions
VEGFR2 mediated vascular permeability
RHO GTPases activate IQGAPs
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle hyperplastic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000088 YSL YSL edematous , abnormal
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 ZFA:0000123 liver liver absent , abnormal
liver decreased size , abnormal
liver increased size , ameliorated
Show

 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism wholly ventralized , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001114 head head necrotic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved ventral , abnormal
post-vent region morphology , abnormal
post-vent region decreased size , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature amount , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000020201 cdc73 / cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) / Q6P1J9* / Q8JZM7* / Parafibromin * / cell division cycle 73*  / complex / reaction
 ENSDARG00000042021 O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000075543 chd8 / chromodomain helicase DNA binding protein 8 / Q09XV5* / Q9HCK8*  / complex / reaction
 ENSDARG00000002591 ruvbl1 / RuvB-like AAA ATPase 1 / P60122* / Q9Y265* / RuvB-like protein 1*  / complex / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000004588 sox4a / SRY (sex determining region Y)-box 4a / SOX4* / Q06945* / Q06831* / SRY-box 4* / Transcription factor SOX-4 *  / complex / reaction
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / reaction / complex
 ENSDARG00000055357 leo1 / Q6NYV9 / LEO1 homolog, Paf1/RNA polymerase II complex component / Q5XJE5* / Q8WVC0* / RNA polymerase-associated protein LEO1 *  / complex / reaction
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex / reaction
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000077226 smarca4a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a / P51532* / Q3TKT4* / SMARCA4* / SWI/SNF related, matrix associated, actin depe...  / complex / reaction
 ENSDARG00000036772 pygo2 / pygopus homolog 2 (Drosophila) / Q9BRQ0* / pygopus 2* / pygopus family PHD finger 2*  / reaction / complex
 ENSDARG00000063229 xpo1b / exportin 1 (CRM1 homolog, yeast) b / XPO1* / O14980* / Q6P5F9* / exportin 1*  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000101717 sox17 / SRY (sex determining region Y)-box 17 / Q9H6I2* / SRY-box 17*  / complex / reaction
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000031894 lef1 / lymphoid enhancer-binding factor 1 / P27782* / Q9UJU2*  / complex / reaction
 ENSDARG00000006409 mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000028793 nlk2 / nemo-like kinase, type 2 / NLK* / O54949* / Q9UBE8* / nemo like kinase* / Serine/threonine-protein kinase NLK *  / reaction
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction
 ENSDARG00000011219 akt2 / v-akt murine thymoma viral oncogene homolog 2 / P31751* / Q60823* / AKT serine/threonine kinase 2* / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA.*  / reaction
 ENSDARG00000038954 ctnnbip1 / catenin, beta interacting protein 1 / Q9NSA3*  / complex / reaction
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000055054 bcl9l / B cell CLL/lymphoma 9-like / Q67FY2* / Q86UU0* / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA.*  / complex / reaction
 ENSDARG00000036687 bcl9 / B cell CLL/lymphoma 9 / O00512* / Q9D219* / B-cell CLL/lymphoma 9 protein *  / complex / reaction
 ENSDARG00000076251 irf3 / interferon regulatory factor 3 / P70671* / Q14653*  / complex / reaction
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000069006 tle3b / O13168 / transducin-like enhancer of split 3b / TLE3* / Q08122* / Q04726* / transducin like enhancer of split 3*  / reaction
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex
 ENSDARG00000100623 trrap / transformation/transcription domain-associated protein / Q9Y4A5*  / complex / reaction






 

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