ENSDARG00000075543


Danio rerio

Features
Gene ID: ENSDARG00000075543
  
Biological name :chd8
  
Synonyms : chd8 / chromodomain helicase DNA binding protein 8
  
Possible biological names infered from orthology : Q09XV5 / Q9HCK8
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 38087413
Gene end: 38117538
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000011455
Ensembl peptide - ENSDARP00000122217
NCBI entrez gene - 568214     See in Manteia.
RefSeq - XM_021481014
RefSeq - NM_001347671
RefSeq Peptide - NP_001334600
swissprot - F1QW70
swissprot - E7FH24
ZFIN ID - ZDB-GENE-030131-6320
Ensembl - ENSDARG00000075543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHD8ENSG00000100888Homo sapiens
 Chd8ENSMUSG00000053754Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chd7 / chromodomain helicase DNA binding protein 7 / A2AJK6* / Q9P2D1*ENSDARG0000007521143
chd9 / chromodomain helicase DNA binding protein 9 / Q3L8U1* / Q8BYH8*ENSDARG0000007449842
chd6 / chromodomain helicase DNA binding protein 6 / Q8TD26*ENSDARG0000001724437
chd3 / chromodomain helicase DNA binding protein 3 / Q12873*ENSDARG0000002140517
chd4b / chromodomain helicase DNA binding protein 4b / CHD4* / Q14839* / Q6PDQ2* / chromodomain helicase DNA binding protein 4* / Mus musculus chromodomain helicase DNA binding protein 4 (C...ENSDARG0000002578917
chd2 / chromodomain helicase DNA binding protein 2 / E9PZM4* / O14647* / AC013394.1*ENSDARG0000006068717
chd4a / chromodomain helicase DNA binding protein 4a / CHD4* / Q14839* / Q6PDQ2* / chromodomain helicase DNA binding protein 4* / Mus musculus chromodomain helicase DNA binding protein 4 (C...ENSDARG0000006353517
chd5 / chromodomain helicase DNA binding protein 5 / A2A8L1* / Q8TDI0*ENSDARG0000010508317
chd1 / chromodomain helicase DNA binding protein 1 / O14646* / P40201* / Q9CQS5*ENSDARG0000010378716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR000953  Chromo/chromo shadow domain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR016197  Chromo-like domain superfamily
 IPR023780  Chromo domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR034724  Chromodomain-helicase-DNA-binding protein 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0060322 head development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain increased size , abnormal
Show

 ZFA:0000107 eye eye increased distance eye , abnormal
Show

 ZFA:0000112 gut gut has fewer parts of type enteric neuron , abnormal
Show

 ZFA:0000445 optic tectum optic tectum increased distance optic tectum , abnormal
Show

 ZFA:0001114 head head increased size , abnormal
Show

 ZFA:0005775 enteric neuron enteric neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr