ENSDARG00000035187


Danio rerio

Features
Gene ID: ENSDARG00000035187
  
Biological name :abl1
  
Synonyms : abl1 / c-abl oncogene 1, non-receptor tyrosine kinase
  
Possible biological names infered from orthology : ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519 / P00520
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 72145468
Gene end: 72168783
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124744
Ensembl peptide - ENSDARP00000125008
NCBI entrez gene - 100000720     See in Manteia.
swissprot - F8W2F9
swissprot - F8W5Q8
ZFIN ID - ZDB-GENE-100812-9
Ensembl - ENSDARG00000035187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ABL1ENSGALG00000003875Gallus gallus
 ABL1ENSG00000097007Homo sapiens
 Abl1ENSMUSG00000026842Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abl2 / c-abl oncogene 2, non-receptor tyrosine kinase / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSDARG0000001384152
btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *ENSDARG0000000443317
fer / fer (fps/fes related) tyrosine kinase / P70451* / P16591* / FER tyrosine kinase* / Tyrosine-protein kinase Fer *ENSDARG0000001219617
itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSDARG0000001756517
fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSDARG0000001144916
csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *ENSDARG0000006799616
matk / megakaryocyte-associated tyrosine kinase / P42679*ENSDARG0000007467015
tec / tec protein tyrosine kinase / P42680*ENSDARG0000009847715
txk / TXK tyrosine kinase / P42681*ENSDARG0000001506810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR033221  Tyrosine-protein kinase ABL1/transforming protein Abl


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
Role of ABL in ROBO-SLIT signaling
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSDARG00000042021 O42376 / mapk12a / mitogen-activated protein kinase 12a / O08911* / MAPK12* / P53778* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000006409 mapk12b / mitogen-activated protein kinase 12b / P53778* / MAPK12* / O08911* / mitogen-activated protein kinase 12*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000004246 slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*  / complex / reaction
 ENSDARG00000005274 rad52 / RAD52 homolog, DNA repair protein / P43351* / P43352*  / reaction
 ENSDARG00000014571 ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*  / complex
 ENSDARG00000013397 bnip2 / BCL2 interacting protein 2 / O54940* / Q12982* / BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 *  / complex
 ENSDARG00000061328 cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *  / complex
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / reaction
 ENSDARG00000068191 cdh15 / cadherin 15, type 1, M-cadherin (myotubule) / P33146* / P55291* / cadherin 15*  / complex
 ENSDARG00000024785 B7ZC77 / ctnna2 / catenin (cadherin-associated protein), alpha 2 / Q61301* / P26232* / catenin alpha 2* / Mus musculus catenin (cadherin associated protein), alpha 2 (Ctnna2), transcript va...  / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000102441 ctnna1 / catenin (cadherin-associated protein), alpha 1 / P26231* / P35221* / catenin alpha 1*  / complex






 

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